Acquisition strategies for spatially resolved magnetic resonance detection of hyperpolarized nuclei

GJ Topping, C Hundshammer, L Nagel… - … Resonance Materials in …, 2020 - Springer
Hyperpolarization is an emerging method in magnetic resonance imaging that allows
nuclear spin polarization of gases or liquids to be temporarily enhanced by up to five or six …

Hyperpolarized 129Xe MRI at low field: Current status and future directions

S Perron, A Ouriadov - Journal of Magnetic Resonance, 2023 - Elsevier
Abstract Magnetic Resonance Imaging (MRI) is dictated by the magnetization of the sample,
and is thus a low-sensitivity imaging method. Inhalation of hyperpolarized (HP) noble gases …

Lung morphometry using hyperpolarized 129Xe apparent diffusion coefficient anisotropy in chronic obstructive pulmonary disease

A Ouriadov, A Farag, M Kirby… - Magnetic resonance …, 2013 - Wiley Online Library
Purpose The goal of this work was to investigate lung morphological changes associated
with chronic obstructive pulmonary disease (COPD) using hyperpolarized 129Xe diffusion …

In vivo regional ventilation mapping using fluorinated gas MRI with an x‐centric FGRE method

AV Ouriadov, MS Fox, MJ Couch, T Li… - Magnetic …, 2015 - Wiley Online Library
Purpose Inert fluorinated gas lung MRI is a new and promising alternative to hyperpolarized
gas lung MRI; it is less expensive and does not require expensive isotopes/polarizers. The …

Fast dynamic ventilation MRI of hyperpolarized 129Xe using spiral imaging

O Doganay, TN Matin, A Mcintyre… - Magnetic resonance …, 2018 - Wiley Online Library
Purpose To develop and optimize a rapid dynamic hyperpolarized 129Xe ventilation (DXeV)
MRI protocol and investigate the feasibility of capturing pulmonary signal‐time curves in …

Hyperpolarized 129Xe imaging of the rat lung using spiral IDEAL

O Doganay, T Wade, E Hegarty… - Magnetic …, 2016 - Wiley Online Library
Purpose To implement and optimize a single‐shot spiral encoding strategy for rapid 2D
IDEAL projection imaging of hyperpolarized (Hp) 129Xe in the gas phase, and in the …

Mapping and correcting hyperpolarized magnetization decay with radial keyhole imaging

PJ Niedbalski, MM Willmering… - Magnetic resonance …, 2019 - Wiley Online Library
Purpose Hyperpolarized (HP) media enable biomedical imaging applications that cannot be
achieved with conventional MRI contrast agents. Unfortunately, quantifying HP images is …

Early stage radiation‐induced lung injury detected using hyperpolarized 129Xe Morphometry: Proof‐of‐concept demonstration in a rat model

A Ouriadov, M Fox, E Hegarty… - Magnetic …, 2016 - Wiley Online Library
Purpose Radiation‐induced lung injury (RILI) is still the major dose‐limiting toxicity related
to lung cancer radiation therapy, and it is difficult to predict and detect patients who are at …

Preclinical MRI Using Hyperpolarized 129Xe

S Kadlecek, Y Friedlander, RS Virgincar - Molecules, 2022 - mdpi.com
Although critical for development of novel therapies, understanding altered lung function in
disease models is challenging because the transport and diffusion of gases over short …

Noninvasive quantification of alveolar morphometry in elderly never‐and ex‐smokers

GA Paulin, A Ouriadov, E Lessard, K Sheikh… - Physiological …, 2015 - Wiley Online Library
Diffusion‐weighted magnetic resonance imaging (MRI) provides a way to generate in vivo
lung images with contrast sensitive to the molecular displacement of inhaled gas at …