The use of fungal cultures have been well documented in human history. Although its used
in healthcare, like penicillin and statins, have saved countless of lives, but there is still no …

Monoclonal antibodies targeting the programmed-death 1 (PD-1) immune checkpoint or its
ligand PD-L1 have significantly improved the treatment of cancers but more efficient drugs …

LncRNA-XIST participated in the regulation of Non-small cell lung cancer (NSCLC)
progression, but the underlying mechanisms are still unclear. This study showed that …

Sphingosine kinase 1 (SphK1) a key enzyme that catalyzes the conversion of sphingosine
(Sph) to sphingosine 1-phosphate (S1P), so as to maintain the dynamic balance of …

Simple Summary Cancer is the prime cause of death globally. The altered stimulation of
signaling pathways controlled by human kinases has often been observed in various human …

Depression is a common aspect of the modern lifestyle, and most patients are recalcitrant to
the current antidepressants. Fingolimod (FTY720), a sphingosine analogue approved for the …

Cancer chemoresistance is a problematic dilemma that significantly restrains numerous
cancer management protocols. It can promote cancer recurrence, spreading of cancer, and …

The post-translational modification and aggregation of alpha-synuclein are one of the major
causes of Parkinson's disease (PD) regulation. In that, the phosphorylation and nitration of …

Summary Sphingosine‐1‐phosphate (S1P) is a bioactive sphingolipid metabolite. The past
decade has witnessed exponential growth in the field of S1P research, partly attributed to …

Parkinson's disease (PD) develops due to oxidative stress, mitochondrial aberrations,
posttranslational modification, and α-Synuclein (α-Syn) aggregation. The α-synucleinopathy …