Extracellular matrix (ECM) is an essential component of skeletal muscle. It provides a
framework structure that holds myofibers and blood capillaries and nerves supplying the …

Duchenne muscular dystrophy (DMD) is a progressive disease caused by the loss of
function of the protein dystrophin. This protein contributes to the stabilisation of striated cells …

As the population is ageing and lifestyle is changing, the prevalence of musculoskeletal
(MSK) disorders is gradually increasing with each passing year, posing a serious threat to …

COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has
been considered a public health emergency, extensively investigated by researchers …

The integration of vascular structures into in vitro cultured tissues provides realistic models
of complex tissue-vascular interactions. Despite the incidence and impact of muscle-wasting …

We developed an on-slide decellularization approach to generate acellular extracellular
matrix (ECM) myoscaffolds that can be repopulated with various cell types to interrogate cell …

Becker muscular dystrophy (BMD) is a severe X-linked muscle disease. Age of onset,
clinical variability, speed of progression and affected tissues display wide variability, making …

Volumetric muscle loss (VML) resulting from extremity trauma presents functional deficits
and fibrosis, ultimately manifesting disability. The extensive fibrotic accumulation is expected …

Macrophages play an essential role in skeletal muscle regeneration. The phagocytosis of
muscle cell debris induces a switch of pro-inflammatory macrophages into an anti …

Myeloid cells are critical to the development of fibrosis following muscle injury; however, the
mechanism of their role in fibrosis formation remains unclear. In this study, we demonstrate …