Apical constriction is a cell shape change that promotes tissue remodeling in a variety of
homeostatic and developmental contexts, including gastrulation in many organisms and …

Cell migration is fundamental to establishing and maintaining the proper organization of
multicellular organisms. Morphogenesis can be viewed as a consequence, in part, of cell …

Many genes and molecules that drive tissue patterning during organogenesis and tissue
regeneration have been discovered. Yet, we still lack a full understanding of how these …

Background Epithelial junctional networks assume packing geometries characterized by
different cell shapes, neighbor number distributions and areas. The development of specific …

Apical constriction facilitates epithelial sheet bending and invagination during
morphogenesis,. Apical constriction is conventionally thought to be driven by the continuous …

Embryonic morphogenesis requires the execution of complex mechanisms that regulate the
local behaviour of groups of cells. The orchestration of such mechanisms has been mainly …

Mechanotransduction research has focused historically on how externally applied forces
can affect cell signalling and function. A growing body of evidence suggests that contractile …

Cell shape changes underlie a large set of biological processes ranging from cell division to
cell motility. Stereotyped patterns of cell shape changes also determine tissue remodeling …

Axis elongation in Drosophila occurs through polarized cell rearrangements driven by
actomyosin contractility. Myosin II promotes neighbor exchange through the contraction of …

Contractile forces generated by the actomyosin cytoskeleton within individual cells
collectively generate tissue-level force during epithelial morphogenesis. During Drosophila …