Biomolecular condensates appear throughout cell physiology and pathology, but the
specific role of condensation or its dynamics is often difficult to determine. Optogenetics …

Abstract β-Catenin is a well-established driver of many cancers; however, there are
challenges in developing agents targeting β-catenin for clinical use. Recent progress has …

Peroxisomes are membrane-bound organelles harboring metabolic enzymes. In humans,
peroxisomes are required for normal development, yet the genes regulating peroxisome …

The Wnt/β-catenin signaling pathway plays numerous essential roles in animal development
and tissue/stem cell maintenance. The activation of genes regulated by Wnt/β-catenin …

The liquid–liquid phase separation (LLPS) of biomolecules induces condensed assemblies
called liquid droplets or membrane-less organelles. In contrast to organelles with lipid …

Wnt/β-catenin signaling is a critical pathway that influences development and therapeutic
response of non-small cell lung cancer (NSCLC). In recent years, many Wnt regulators …

Phase separation, a process in which biomolecules segregate into distinct liquid-like
compartments within cells, has recently been identified as a crucial regulator of various …

Colorectal cancer (CRC) ranks as the third most prevalent malignancy worldwide. Despite
the gradual expansion of therapeutic options for CRC, its clinical management remains a …

Colorectal cancer is the third leading cause of cancer deaths worldwide, and, thus,
understanding genetic changes driving cancer development and progression is critical. A …

Human gastrulation is a critical stage of development where many pregnancies fail due to
poorly understood mechanisms. Using the 2D gastruloid, a stem cell model of human …