[HTML][HTML] Human breast milk exosomes: affecting factors, their possible health outcomes, and future directions in dietetics
Background: Human breast milk is a complex biological fluid containing multifaceted
biological compounds that boost immune and metabolic system development that support …
biological compounds that boost immune and metabolic system development that support …
Alternative methods as tools for obesity research: In vitro and in silico approaches
JH Pamplona, B Zoehler, P Shigunov, MJ Barisón… - Life, 2022 - mdpi.com
The study of adipogenesis is essential for understanding and treating obesity, a
multifactorial problem related to body fat accumulation that leads to several life-threatening …
multifactorial problem related to body fat accumulation that leads to several life-threatening …
Lipid nanoparticles as a shuttle for anti-adipogenic miRNAs to human adipocytes
AL Schachner-Nedherer, J Fuchs, I Vidakovic, O Höller… - Pharmaceutics, 2023 - mdpi.com
Obesity and type 2 diabetes are major health burdens for which no effective therapy is
available today. One treatment strategy could be to balance the metabolic functions of …
available today. One treatment strategy could be to balance the metabolic functions of …
Strategy for pre-clinical development of active targeting MicroRNA oligonucleotide therapeutics for unmet medical needs
M Thibonnier, S Ghosh - International Journal of Molecular Sciences, 2023 - mdpi.com
We present here an innovative modular and outsourced model of drug research and
development for microRNA oligonucleotide therapeutics (miRNA ONTs). This model is being …
development for microRNA oligonucleotide therapeutics (miRNA ONTs). This model is being …
Sex-specific regulation of miR-22 and ERα in white adipose tissue of obese dam's female offspring impairs the early postnatal development of functional beige …
É de Sousa, M de Mendonça, AP Bolin… - … et Biophysica Acta (BBA …, 2024 - Elsevier
During inguinal adipose tissue (iWAT) ontogenesis, beige adipocytes spontaneously appear
between postnatal 10 (P10) and P20 and their ablation impairs iWAT browning capacity in …
between postnatal 10 (P10) and P20 and their ablation impairs iWAT browning capacity in …
[HTML][HTML] Adipose Tissue Macrophages of the Human Fetus
Á Radványi, K Gyurina, E Rácz, I Kovács, G Méhes… - Cells, 2024 - pmc.ncbi.nlm.nih.gov
Prenatal adipose tissue development affects body composition and growth trajectory in early
infancy, therefore it is a key determinant of adiposity in childhood. Childhood overweight and …
infancy, therefore it is a key determinant of adiposity in childhood. Childhood overweight and …
[HTML][HTML] Succinic Acid Improves the Metabolism of High-Fat Diet-Induced Mice and Promotes White Adipose Browning
Y Yang, L Luo, Y Li, X Shi, C Li, J Chai, S Jiang… - Nutrients, 2024 - mdpi.com
Succinic acid plays a crucial role as an essential intermediate in the mitochondrial
tricarboxylic acid cycle in mitochondria. In recent years, growing evidence has supported the …
tricarboxylic acid cycle in mitochondria. In recent years, growing evidence has supported the …
[HTML][HTML] Multiple Genetic Polymorphisms within microRNA Targets and Homologous microRNA-Binding Sites: Two More Factors Influencing microRNA-Mediated …
M Giurgiu, R Kaltenbach, F Ahrend, S Weeks, H Clifton… - 2023 - intechopen.com
Abstract miRNA-mRNA interaction depends on multiple factors such as 3'UTR isoforms, the
cell and tissue-specific expression levels of RNA-binding proteins, the sequence context …
cell and tissue-specific expression levels of RNA-binding proteins, the sequence context …