Historical perspective on the discovery of the quasispecies concept

E Domingo, C García-Crespo… - Annual review of …, 2021 - annualreviews.org
Viral quasispecies are dynamic distributions of nonidentical but closely related mutant and
recombinant viral genomes subjected to a continuous process of genetic variation …

Recurrent HBV integration targets as potential drivers in hepatocellular carcinoma

SY Lin, A Zhang, J Lian, J Wang, TT Chang, YJ Lin… - Cells, 2021 - mdpi.com
Chronic hepatitis B virus (HBV) infection is the major etiology of hepatocellular carcinoma
(HCC), frequently with HBV integrating into the host genome. HBV integration, found in 85 …

[HTML][HTML] The oncogenic role of hepatitis B virus X gene in hepatocarcinogenesis: recent updates

A Agustiningsih, MR Rasyak, S Jayanti… - … of Targeted Anti …, 2024 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancers with
high mortality rate. Among its various etiological factors, one of the major risk factors for HCC …

Synergistic effect of MC-LR and C-terminal truncated HBx on HepG2 cells and their effects on PP2A mediated downstream target of MAPK signaling pathway

C Xiao, F Mei, G Ren, L Long, M Chen, X Fang… - Frontiers in …, 2020 - frontiersin.org
C-terminally truncated hepatitis B virus (HBV) X (ctHBx) infection and exposure to
microcystins-LR (MC-LR) can lead to human hepatitis and liver cancer, but the mechanism …

The abnormal proliferation of hepatocytes is associated with MC-LR and C-terminal truncated HBX synergistic disturbance of the redox balance

DM Cai, FB Mei, CJ Zhang, SC An, RB Lv… - Journal of …, 2022 - Taylor & Francis
Background Microcystin-LR (MC-LR) and hepatitis B virus (HBV) are associated with
hepatocellular carcinoma (HCC). However, the concentrations of MC-LR in drinking water …

Regulation and Impact of Hepatitis B x protein in persistence and oncogenesis of Hepatitis B Virus

G Garg, S Purwar, AK Singh, AK Vyas - 2022 - preprints.org
Abstract Chronic Hepatitis B (CHB) Virus infection is major etiological factor for liver cirrhosis
and/or liver cancer. The viral protein, major contributor in predisposition of chronicity and …

First Molecular Characterization of Chronic Hepatitis B Carriers in Timbuktu, Mali

P Lawrence, M Chabane, L Abrouk, A Thiesson… - Diagnostics, 2023 - mdpi.com
In Mali, hepatocellular carcinoma (HCC) is the third and sixth most common cancer in men
and women, respectively. Mali comprises several distinct climato-ecological zones. Most …

Method and kit for hbv-host junction sequence identification, and use thereof in hepatocellular carcinoma characterization

LIN Selena, W Song - US Patent App. 16/932,434, 2021 - Google Patents
US20210017611A1 - Method and kit for hbv-host junction sequence identification, and use
thereof in hepatocellular carcinoma characterization - Google Patents US20210017611A1 …