Antiretroviral therapy (ART), while essential in combatting tuberculosis (TB) and HIV
coinfection, is often complicated by the TB-associated immune reconstitution inflammatory …

Objective To make an informed viewpoint on the usefulness of Tuberculin Skin test (TST)
compared to Interferon Gamma Release Assays (IGRAs) for diagnosis of Latent TB Infection …

Objectives IFNγ-release assays (IGRAs) used for diagnosis of Mycobacterium (M.)
tuberculosis infection have limited sensitivity. Alternative cytokines and M. tuberculosis …

Background Tuberculosis (TB) clinical prediction rules rely on presence of symptoms,
however many undiagnosed cases in the community are asymptomatic. This study aimed to …

Purpose: To determine the utility of interferon-gamma-inducible protein 10 (IP-10) for
identifying active tuberculosis (TB) and TB infection (TBI) in children in BCG-vaccinated …

Management of latent tuberculosis infection (LTBI) is a critical element in the elimination of
tuberculosis (TB). However, the low positive predictive value of the current diagnostic tests …

Realizing ambitious international HIV and TB targets in prisons will only be possible by first
addressing the root causes of the TB/HIV syndemic, which are deeply intertwined with …

A new paradigm in neuroscience has recently emerged–the brain–gut axis (BGA). The
contemporary focus in this paradigm has been gut→ brain (“bottom-up”), in which the gut …

Background The tuberculin skin test (TST) and interferon-gamma-release-assays (IGRAs)
are utilized in screening programmes for presumed latent tuberculosis infection (LTBI) in …

Background. Immune parameters (IP) have been extensively studied to distinguish between
latent tuberculosis (LTBI) and active tuberculosis (TB). Objective. To determine the IP …