Systemic inflammation can be triggered by infection, surgery, trauma or burns. During
systemic inflammation, an overshooting immune response induces tissue damage resulting …

A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

Endothelial cells line blood vessels and provide a dynamic interface between the blood and
tissues. They remodel to allow leukocytes, fluid and small molecules to enter tissues during …

Neutrophils represent the first line of cellular defense against invading microorganism by
rapidly moving across the blood–endothelial cell (EC) barrier and exerting effector cell …

Calcium is an essential second messenger in endothelial cells and plays a pivotal role in
regulating a number of physiologic processes, including cell migration, angiogenesis …

The endothelial barrier consists of intercellular contacts localized in the cleft between
endothelial cells, which is covered by the glycocalyx in a sievelike manner. Both types of …

Abstract Purpose of the Review In this review, we summarize current insights into the
versatile roles of endothelial cells in atherogenesis. Recent Findings The vascular …

Glutamine synthetase, encoded by the gene GLUL, is an enzyme that converts glutamate
and ammonia to glutamine. It is expressed by endothelial cells, but surprisingly shows …

The regulation of polymorphonuclear leukocyte (PMN) function by mechanical forces
encountered during their migration across restrictive endothelial cell junctions is not well …

Immune responses are dependent on the recruitment of leukocytes to the site of
inflammation. The classical leukocyte recruitment cascade, consisting of capture, rolling …