Fever and the thermal regulation of immunity: the immune system feels the heat

SS Evans, EA Repasky, DT Fisher - Nature Reviews Immunology, 2015 - nature.com
Fever is a cardinal response to infection that has been conserved in warm-blooded and cold-
blooded vertebrates for more than 600 million years of evolution. The fever response is …

Physiologic and pharmacologic considerations for hypothermia therapy in neonates

S Zanelli, M Buck, K Fairchild - Journal of Perinatology, 2011 - nature.com
With mounting evidence that hypothermia is neuroprotective in newborns with hypoxic-
ischemic encephalopathy (HIE), an increasing number of centers are offering this therapy …

Regulation of macrophage polarization through periodic photo‐thermal treatment to facilitate osteogenesis

B Li, F Liu, J Ye, X Cai, R Qian, K Zhang, Y Zheng… - Small, 2022 - Wiley Online Library
The richened reactive oxygen species (ROS) and their derived excessive inflammation at
bone injured sites hinder osteogenesis of endosseous Ti‐based implants. Herein, anti …

Inflammatory response to magnesium-based biodegradable implant materials

MD Costantino, A Schuster, H Helmholz… - Acta biomaterialia, 2020 - Elsevier
Biodegradability and mechanical properties of magnesium alloys are attractive for
orthopaedic and cardiovascular applications. In order to study their cytotoxicity usually bone …

Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy

LF Chalak, PJ Sánchez, B Adams-Huet… - The Journal of …, 2014 - Elsevier
Objective To evaluate serum neuronal and inflammatory biomarkers to determine whether
measurements of umbilical cords at birth can stratify severity of hypoxic-ischemic …

Transient mild photothermia improves therapeutic performance of oral nanomedicines with enhanced accumulation in the colitis mucosa

Y Ma, S Gou, Z Zhu, J Sun, MA Shahbazi… - Advanced …, 2024 - Wiley Online Library
The treatment outcomes of oral medications against ulcerative colitis (UC) have long been
restricted by low drug accumulation in the colitis mucosa and subsequent unsatisfactory …

HSP70 is a negative regulator of NLRP3 inflammasome activation

P Martine, A Chevriaux, V Derangère, L Apetoh… - Cell death & …, 2019 - nature.com
The NOD-leucine rich repeat and pyrin containing protein 3 (NLRP3) inflammasome is a
multi-protein complex, aimed at producing IL-1β in response to danger signals which must …

Unintentional perioperative hypothermia is associated with severe complications and high mortality in elective operations

AT Billeter, SF Hohmann, D Druen, R Cannon… - Surgery, 2014 - Elsevier
Introduction Hypothermia occurs in as many as 7% of elective colorectal operations and is
an underestimated risk factor for complications and death. Rewarming of hypothermic …

Pathophysiologic changes and effects of hypothermia on outcome in elective surgery and trauma patients

F Hildebrand, PV Giannoudis, M van Griensven… - The American Journal of …, 2004 - Elsevier
Generally, hypothermia is defined as a core temperature< 35° C. In elective surgery,
induced hypothermia has beneficial effects. It is recommended to diminish complications …

A high affinity HSF-1 binding site in the 5′-untranslated region of the murine tumor necrosis factor-α gene is a transcriptional repressor

IS Singh, JR He, S Calderwood, JD Hasday - Journal of Biological …, 2002 - ASBMB
Tumor necrosis factor-α (TNFα) is a pivotal early mediator of host defenses that is essential
for survival in infections. We previously reported that exposing macrophages to febrile range …