Protein disulfide isomerase: a promising target for cancer therapy
S Xu, S Sankar, N Neamati - Drug discovery today, 2014 - Elsevier
Highlights•PDI is an important oxidase, reductase, isomerase and molecular
chaperone.•PDI expression is up-regulated in select types of cancers.•Silencing PDI results …
chaperone.•PDI expression is up-regulated in select types of cancers.•Silencing PDI results …
Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease: chemical synthesis, biological evaluation, molecular docking and 3D …
L Wang, BB Bao, GQ Song, C Chen, XM Zhang… - European Journal of …, 2017 - Elsevier
The worldwide outbreak of severe acute respiratory syndrome (SARS) in 2003 had caused a
high rate of mortality. Main protease (M pro) of SARS-associated coronavirus (SARS-CoV) is …
high rate of mortality. Main protease (M pro) of SARS-associated coronavirus (SARS-CoV) is …
Anti-HIV activity of semisynthetic derivatives of andrographolide and computational study of HIV-1 gp120 protein binding
MM Uttekar, T Das, RS Pawar, B Bhandari… - European journal of …, 2012 - Elsevier
Andrographolide, a diterpene lactone of the Andrographis paniculata, displays anti-HIV
activity in vitro. A series of andrographolide derivatives have been synthesized and …
activity in vitro. A series of andrographolide derivatives have been synthesized and …
The role of cellular oxidoreductases in viral entry and virus infection-associated oxidative stress: potential therapeutic applications
L Mathys, J Balzarini - Expert opinion on therapeutic targets, 2016 - Taylor & Francis
Introduction: Cellular oxidoreductases catalyze thiol/disulfide exchange reactions in
susceptible proteins and contribute to the cellular defense against oxidative stress …
susceptible proteins and contribute to the cellular defense against oxidative stress …
Cell-type specific requirements for thiol/disulfide exchange during HIV-1 entry and infection
TS Stantchev, M Paciga, CR Lankford, F Schwartzkopff… - Retrovirology, 2012 - Springer
Background The role of disulfide bond remodeling in HIV-1 infection is well described, but
the process still remains incompletely characterized. At present, the data have been …
the process still remains incompletely characterized. At present, the data have been …
Antibiotic bacitracin induces hydrolytic degradation of nucleic acids
J Ciesiołka, M Jeżowska-Bojczuk, J Wrzesiński… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Background Bacitracin is a polypeptide antibiotic active against Gram-positive bacterial
strains. Its mechanism of action postulates disturbing the cell wall synthesis by inhibiting …
strains. Its mechanism of action postulates disturbing the cell wall synthesis by inhibiting …
Functions and mechanisms of protein disulfide isomerase family in cancer emergence
NSA Rahman, S Zahari, SE Syafruddin… - Cell & Bioscience, 2022 - Springer
The endoplasmic reticulum (ER) is a multi-layered organelle that is essential for the
synthesis, folding, and structural maturation of almost one-third of the cellular proteome. It …
synthesis, folding, and structural maturation of almost one-third of the cellular proteome. It …
Entry inhibitors directed towards glycoprotein gp120: an overview on a promising target for HIV-1 therapy
A Flores, E Quesada - Current medicinal chemistry, 2013 - ingentaconnect.com
In spite of the unquestionable positive impact of HAART in the treatment of HIV infection, the
discovery and development of novel agents directed towards other targets of the replicative …
discovery and development of novel agents directed towards other targets of the replicative …
Investigation of the antimicrobial efficacy and cytotoxicity of a natural disinfectant Syzygium cumini (L.) skeels leaf extract on vero cell lines
HJ Devi, P Gnanasekaran, YA Devi, D Siva… - Journal of Applied …, 2024 - japsonline.com
Disinfectants are vital for infection prevention and environmental health maintenance.
However, the use of chemical disinfectants has adverse effects on human health, including …
However, the use of chemical disinfectants has adverse effects on human health, including …
Synthesis of Symmetrical Disulfides by an NIS/PPh3-Mediated Reductive Self-Coupling of Sulfonyl Hydrazides
The present study discloses an NIS/PPh 3-mediated reductive self-coupling of arylsulfonyl
hydrazides to prepare symmetric diaryl disulfides. This methodology has a broad functional …
hydrazides to prepare symmetric diaryl disulfides. This methodology has a broad functional …