Homeostatic control of Drosophila neuromuscular junction function
The ability to adapt to changing internal and external conditions is a key feature of biological
systems. Homeostasis refers to a regulatory process that stabilizes dynamic systems to …
systems. Homeostasis refers to a regulatory process that stabilizes dynamic systems to …
A genetic, genomic, and computational resource for exploring neural circuit function
The anatomy of many neural circuits is being characterized with increasing resolution, but
their molecular properties remain mostly unknown. Here, we characterize gene expression …
their molecular properties remain mostly unknown. Here, we characterize gene expression …
Synaptic properties and plasticity mechanisms of invertebrate tonic and phasic neurons
NA Aponte-Santiago, JT Littleton - Frontiers in Physiology, 2020 - frontiersin.org
Defining neuronal cell types and their associated biophysical and synaptic diversity has
become an important goal in neuroscience as a mechanism to create comprehensive brain …
become an important goal in neuroscience as a mechanism to create comprehensive brain …
High dietary sugar reshapes sweet taste to promote feeding behavior in Drosophila melanogaster
Recent studies find that sugar tastes less intense to humans with obesity, but whether this
sensory change is a cause or a consequence of obesity is unclear. To tackle this question …
sensory change is a cause or a consequence of obesity is unclear. To tackle this question …
Physiologic and nanoscale distinctions define glutamatergic synapses in tonic vs phasic neurons
Neurons exhibit a striking degree of functional diversity, each one tuned to the needs of the
circuitry in which it is embedded. A fundamental functional dichotomy occurs in activity …
circuitry in which it is embedded. A fundamental functional dichotomy occurs in activity …
Endogenous tagging reveals differential regulation of Ca2+ channels at single active zones during presynaptic homeostatic potentiation and depression
SJ Gratz, P Goel, JJ Bruckner… - Journal of …, 2019 - Soc Neuroscience
Neurons communicate through Ca2+-dependent neurotransmitter release at presynaptic
active zones (AZs). Neurotransmitter release properties play a key role in defining …
active zones (AZs). Neurotransmitter release properties play a key role in defining …
Homeostatic scaling of active zone scaffolds maintains global synaptic strength
Synaptic terminals grow and retract throughout life, yet synaptic strength is maintained within
stable physiological ranges. To study this process, we investigated Drosophila endophilin …
stable physiological ranges. To study this process, we investigated Drosophila endophilin …
Dietary sugar inhibits satiation by decreasing the central processing of sweet taste
From humans to vinegar flies, exposure to diets rich in sugar and fat lowers taste sensation,
changes food choices, and promotes feeding. However, how these peripheral alterations …
changes food choices, and promotes feeding. However, how these peripheral alterations …
A glutamate receptor C-tail recruits CaMKII to suppress retrograde homeostatic signaling
Presynaptic homeostatic plasticity (PHP) adaptively enhances neurotransmitter release
following diminished postsynaptic glutamate receptor (GluR) functionality to maintain …
following diminished postsynaptic glutamate receptor (GluR) functionality to maintain …
Botulinum neurotoxin accurately separates tonic vs. phasic transmission and reveals heterosynaptic plasticity rules in Drosophila
In developing and mature nervous systems, diverse neuronal subtypes innervate common
targets to establish, maintain, and modify neural circuit function. A major challenge towards …
targets to establish, maintain, and modify neural circuit function. A major challenge towards …