Longitudinal single-cell RNA-seq analysis reveals stress-promoted chemoresistance in metastatic ovarian cancer
Chemotherapy resistance is a critical contributor to cancer mortality and thus an urgent
unmet challenge in oncology. To characterize chemotherapy resistance processes in high …
unmet challenge in oncology. To characterize chemotherapy resistance processes in high …
Mechanisms of Ovarian Cancer-Associated Cachexia
CS Callaway, LM Mouchantat, BG Bitler… - Endocrinology, 2024 - academic.oup.com
Cancer-associated cachexia occurs in 50% to 80% of cancer patients and is responsible for
20% to 30% of cancer-related deaths. Cachexia limits survival and treatment outcomes, and …
20% to 30% of cancer-related deaths. Cachexia limits survival and treatment outcomes, and …
Regulatory role of the adipose microenvironment on ovarian cancer progression
H Chehade, R Tedja, H Ramos, TS Bawa… - Cancers, 2022 - mdpi.com
Simple Summary Adipocytes or fat cells are integral part of the ovarian tumor
microenvironment. Secreted factors from adipocytes, as well as direct cell-to-cell interaction …
microenvironment. Secreted factors from adipocytes, as well as direct cell-to-cell interaction …
The SETDB1–TRIM28 complex suppresses antitumor immunity
The tumor immune microenvironment is influenced by the epigenetic landscape of the
tumor. Here, we have identified the SETDB1–TRIM28 complex as a critical suppressor of …
tumor. Here, we have identified the SETDB1–TRIM28 complex as a critical suppressor of …
Spatial transcriptomics reveals discrete tumour microenvironments and autocrine loops within ovarian cancer subclones
High-grade serous ovarian carcinoma (HGSOC) is genetically unstable and characterised
by the presence of subclones with distinct genotypes. Intratumoural heterogeneity is linked …
by the presence of subclones with distinct genotypes. Intratumoural heterogeneity is linked …
A novel ALDH1A1 inhibitor blocks platinum-induced senescence and stemness in ovarian cancer
V Muralikrishnan, F Fang, TC Given, R Podicheti… - Cancers, 2022 - mdpi.com
Simple Summary Ovarian cancer is the deadliest amongst the gynecologic malignancies.
Most ovarian cancer patients initially respond to chemotherapy but will eventually relapse …
Most ovarian cancer patients initially respond to chemotherapy but will eventually relapse …
Analysis of tumor microenvironment characteristics in bladder cancer: implications for immune checkpoint inhibitor therapy
The tumor microenvironment (TME) plays a crucial role in cancer progression and recent
evidence has clarified its clinical significance in predicting outcomes and efficacy. However …
evidence has clarified its clinical significance in predicting outcomes and efficacy. However …
The spatial context of tumor-infiltrating immune cells associates with improved ovarian cancer survival
B Steinhart, KR Jordan, J Bapat, MD Post… - Molecular Cancer …, 2021 - AACR
Ovarian cancer is the deadliest gynecologic malignancy. Multi-omics techniques have
provided a platform for improved predictive modeling of therapy response and patient …
provided a platform for improved predictive modeling of therapy response and patient …
SIGNET: single-cell RNA-seq-based gene regulatory network prediction using multiple-layer perceptron bagging
High-throughput single-cell RNA-seq data have provided unprecedented opportunities for
deciphering the regulatory interactions among genes. However, such interactions are …
deciphering the regulatory interactions among genes. However, such interactions are …
High tumor-infiltrating lymphocyte count is Associated with distinct gene expression Profile and longer patient survival in Advanced Ovarian Cancer
AJ Barna, Z Herold, M Acs, S Bazsa, J Gajdacsi… - International Journal of …, 2023 - mdpi.com
Cancer-related immunity plays a significant role in the outcome of ovarian cancer, but the
exact mechanisms are not fully explored. A retrospective, real-life observational study was …
exact mechanisms are not fully explored. A retrospective, real-life observational study was …