Genetic resistance to infectious diseases is likely to involve a complex array of immune-
response and other genes with variants that impose subtle but significant consequences on …

Exceptional efforts have been undertaken to shed light into the biology of adaptive immune
responses to SARS-CoV-2. T cells occupy a central role in adaptive immunity to mediate …

Individuals with potential exposure to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) do not necessarily develop PCR or antibody positivity, suggesting that some …

The development of an effective human immunodeficiency virus type 1 (HIV-1) vaccine is
likely to depend on knowledge of circulating variants of genes other than the commonly …

We examined the regulation of virus-specific CD8 T cell responses during chronic
lymphocytic choriomeningitis virus (LCMV) infection of mice. Our study shows that within the …

Rare individuals have been multiply exposed to HIV-1 but remain uninfected. The CD4+ T-
cells of two of these individuals, designated EU2 and EU3, are highly resistant in vitro to the …

To determine the role of CD8+ T cells in controlling simian immunodeficiency virus (SIV)
replication in vivo, we examined the effect of depleting this cell population using an anti-CD8 …

A selective advantage against infectious disease associated with increased heterozygosity
at the human major histocompatibility complex [human leukocyte antigen (HLA) class I and …

Abstract A 32–nucleotide deletion (δ32) within the β–chemokine receptor 5 (CCR5) gene
has been described in subjects who remain uninfected despite extensive exposure to HIV …

The HIV-1-specific cytotoxic T lymphocyte (CTL) response is temporally associated with the
decline in viremia during primary HIV-1 infection, but definitive evidence that it is of …