The epidemiological neuropathology perspective of population and community‐based
studies allows unbiased assessment of the prevalence of various pathologies and their …

The pathological hallmark of Alzheimer's disease (AD), the leading cause of senile
dementia, involves region-specific neuronal death and an accumulation of neuronal and …

White matter lesions (WML) are common in brain aging and are associated with dementia.
We aimed to investigate whether oxidative DNA damage and occur in WML and in …

We here describe the study-design major findings from the neuropathological component of
the Medical Research Council Cognitive Function and Aging Study (MRC CFAS). MRC …

Impairment of the blood brain barrier (BBB) in human brain ageing and its relationship to
Alzheimer-type pathology remains poorly defined. We have investigated the BBB in …

Background: Glial tau pathology is seen in certain tauopathies and in ageing. We
determined its frequency in ageing mesial temporal lobe and its relationship to other tau …

Aims Abnormalities of the brain microvasculature in A lzheimer's disease have led to the
vascular hypothesis of the disease, which predicts that vascular changes precede neuronal …

Altered cholesterol metabolism is implicated in brain ageing and Alzheimer's disease. We
examined whether key genes regulating cholesterol metabolism and levels of brain …

Diabetes mellitus is a risk factor for dementia, and nonenzymatic glycosylation of
macromolecules results in formation of advanced glycation end-products (AGEs). We …

Alzheimer's disease (AD) is a progressive neurodegenerative disease and in its familial form
is associated with mutations in the amyloid precursor protein (APP) and the presenilins …