Doxorubicin (DOX) is widely used as a broad-spectrum anti-tumor anthracycline to treat
various cancers. The serious adverse effects of DOX on cardiotoxicity limit its clinical …

Doxorubicin is utilized for anti-neoplastic treatment for several decades. The utility of this
drug is limited due to its side effects. Generally, doxorubicin toxicity is originated from the …

Shenmai injection (SMI), as a patented traditional Chinese medicine, is extracted from
Panax ginseng and Ophiopogon japonicus. It commonly used in the treatment of …

Doxorubicin (DOX) is a potent anti-cancer antibiotic that was widely used for treatment of
various cancers. It produces free radicals which result in extreme dose-limiting cardiotoxicity …

Doxorubicin‐induced cardiotoxicity is the leading cause of morbidity and mortality among
cancer survivors. The present study was aimed to investigate the cardioprotective potential …

Despite the effectiveness of doxorubicin (DOX) in the management of a wide range of
cancers, a major challenge is its cardio-toxic effect. Oxidative stress, inflammation, and …

Damage to the mitochondria may lead to serious conditions that are difficult to treat.
Doxorubicin is one of the most widely used chemotherapeutic drugs for the treatment of …

Doxorubicin (Dox) is a widely used powerful chemotherapeutic component for cancer
treatment. However, its clinical application has been hampered due to doxorubicin-induced …

Anticancer agents can cause various side effects, including tissue damages/inflammatory
reactions. Drug-responsive biomarkers are essential for evaluating drug toxicity in disease …

Cancer treatment with Doxorubicin (DOX) is limited due its dose-dependent cardiotoxicity,
mainly related to the oxidative stress production. In experimental models of DOX treatment …