Chromatin immunoprecipitation followed by sequencing (ChIP-seq) analysis can detect
protein/DNA-binding and histone-modification sites across an entire genome. Recent …

The molecular mechanisms underlying folding of mammalian chromosomes remain poorly
understood. The transcription factor CTCF is a candidate regulator of chromosomal …

Congenital heart disease (CHD) is present in 1% of live births, yet identification of causal
mutations remains challenging. We hypothesized that genetic determinants for CHDs may …

Technology for measuring 3D genome topology is increasingly important for studying gene
regulation, for genome assembly and for mapping of genome rearrangements. Hi-C and …

Differentiation proceeds along a continuum of increasingly fate-restricted intermediates,
referred to as canalization,. Canalization is essential for stabilizing cell fate, but the …

Nutrition and metabolism are known to influence chromatin biology and epigenetics through
post-translational modifications, yet how this interaction influences genomic architecture and …

Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is an important tool for
studying gene regulatory proteins, such as transcription factors and histones. Peak calling is …

BET proteins commonly activate cellular gene expression, yet inhibiting their recruitment
paradoxically reactivates latent HIV-1 transcription. Here we identify the short isoform of BET …

Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is the most popular
assay to identify genomic regions, called ChIP-seq peaks, that are bound in vivo by …

Objective Homozygous loss-of-function mutations in the gene coding for the homeobox
transcription factor (TF) PDX1 leads to pancreatic agenesis, whereas heterozygous …