Gold-based medicine: a paradigm shift in anti-cancer therapy?

CI Yeo, KK Ooi, ERT Tiekink - Molecules, 2018 - mdpi.com
A new era of metal-based drugs started in the 1960s, heralded by the discovery of potent
platinum-based complexes, commencing with cisplatin [(H3N) 2PtCl2], which are effective …

[HTML][HTML] Metal-based compounds containing selenium: An appealing approach towards novel therapeutic drugs with anticancer and antimicrobial effects

S Ramos-Inza, D Plano, C Sanmartín - European Journal of Medicinal …, 2022 - Elsevier
In recent years, both metal-based complexes and selenium-containing compounds have
been widely explored for their therapeutic properties due to their roles in biological …

In vitro and in vivo antitumor studies of potential anticancer agents of platinum(II) complexes of dicyclopentadiene and dithiocarbamates

AAA Sulaiman, HMA Sobeai, E Aldawood… - Metallomics, 2022 - academic.oup.com
Three platinum (II) complexes of dicyclopentadiene (DCP) and dithiocarbamates (DTCs),
namely,[Pt (η4-DCP)(Me2DTC)] PF6 (1),[Pt (η4-DCP)(Et2DTC)] PF6 (2), and [Pt (η4 …

1, 3‐Diazepine: A privileged scaffold in medicinal chemistry

Y Malki, J Martinez, N Masurier - Medicinal Research Reviews, 2021 - Wiley Online Library
Privileged structures have been widely used as effective templates for drug discovery. While
benzo‐1, 4‐diazepine constitutes the first historical example of such a structure, the 1, 3 …

Exploring diversity in platinum (IV) N-heterocyclic carbene complexes: Synthesis, characterization, reactivity and biological evaluation

M Bouché, A Bonnefont, T Achard… - Dalton …, 2018 - pubs.rsc.org
Platinum (IV) complexes stabilized by N-heterocyclic carbene ligands of the type [(NHC)
PtX4L], where L is a neutral nitrogen-based ligand and X is a halide anion (Br, Cl), were …

Organoselenium transition metal complexes as promising candidates in medicine area

M Kostić, J Marjanović, V Divac - JBIC Journal of Biological Inorganic …, 2024 - Springer
The medicinal properties of transition metal complexes are greatly influenced by the nature
and physico-chemical features of the ligand present in the complex structure. Due to the …

[HTML][HTML] New gold (III) cyanide complex TGS 121 induces ER stress, proteasome inhibition and death of Ras-hyperactivated cells

S Lipiec, A Gurba, IM Agnieszczak… - Toxicology in Vitro, 2023 - Elsevier
Metal-based agents in cancer therapy, like cisplatin and its derivates, have established
clinical applications but also can induce serious side effects. Thus, metallotherapeutic …

Antitumor potential of platinum (II) complexes of selenium donor ligands

S Ahmad, AA Isab, AR Al-Arfaj - Metallomics, 2023 - academic.oup.com
Platinum (II) coordination compounds are widely applied in clinics as anticancer drugs. In
this review, we provide a summary of the reports on cytotoxic properties of platinum (II) …

Synthesis, X-ray structure and cytotoxicity evaluation of carbene-based gold (I) complexes of selenones

AAA Seliman, M Altaf, AT Onawole, A Al-Saadi… - Inorganica Chimica …, 2018 - Elsevier
Gold (I)-carbene complexes containing a selenone ligand (L),[Au (IPr)(L)] PF 6 {where, IPr=
1, 3-Bis (2, 6-di-isopropylphenyl) imidazol-2-ylidene and L= Ni-propyl-1, 3-imidazolidine-2 …

Bis (selone) complexes of palladium (II), platinum (II), and gold (III): Synthesis and structural studies

V Rani, HB Singh, RJ Butcher - European Journal of Inorganic …, 2017 - Wiley Online Library
New bis (selone)‐based metal complexes,[MnLxCly]{M= Pd, L= 3, 3′‐[(2‐bromo‐1, 3‐
phenylene) bis (methylene)] bis (1‐mesityl‐1, 3‐dihydro‐2H‐imidazole‐2‐selone)(15), n= 2 …