Harnessing prostaglandin E2 signaling to ameliorate autoimmunity

JB Burkett, AC Doran, M Gannon - Trends in immunology, 2023 - cell.com
The etiology of most autoimmune diseases remains unknown; however, shared among them
is a disruption of immunoregulation. Prostaglandin lipid signaling molecules possess …

Investigational drugs for the treatment of postherpetic neuralgia: systematic review of randomized controlled trials

MA Huerta, MM Garcia, B Garcia-Parra… - International Journal of …, 2023 - mdpi.com
The pharmacological treatment of postherpetic neuralgia (PHN) is unsatisfactory, and there
is a clinical need for new approaches. Several drugs under advanced clinical development …

METTL3-mediated m6A modification of LINC00839 maintains glioma stem cells and radiation resistance by activating Wnt/β-catenin signaling

J Yin, F Ding, Z Cheng, X Ge, Y Li, A Zeng… - Cell death & …, 2023 - nature.com
Long noncoding RNAs (lncRNAs) are involved in glioma initiation and progression. Glioma
stem cells (GSCs) are essential for tumor initiation, maintenance, and therapeutic resistance …

COX 2-inhibitors; a thorough and updated survey into combinational therapies in cancers

P Rodrigues, H Bangali, A Hammoud, YF Mustafa… - Medical Oncology, 2024 - Springer
Cyclooxygenase (COX) enzymes are pivotal in inflammation and cancer development. COX-
2, in particular, has been implicated in tumor growth, angiogenesis, and immune evasion …

Linking dysbiosis to precancerous stomach through inflammation: deeper than and beyond imaging

C Lopes, TC Almeida, P Pimentel-Nunes… - Frontiers in …, 2023 - frontiersin.org
Upper gastrointestinal endoscopy is considered the gold standard for gastric lesions
detection and surveillance, but it is still associated with a non-negligible rate of missing …

Dual COX-2/15-LOX inhibitors: A new avenue in the prevention of cancer

A Aliabadi, E Khanniri, M Mahboubi-Rabbani… - European journal of …, 2023 - Elsevier
Abstract Dual cyclooxygenase 2/15-lipoxygenase inhibitors constitute a valuable alternative
to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 …

The efficacy and safety of celecoxib in addition to standard cancer therapy: a systematic review and meta-analysis of randomized controlled trials

SY Ye, JY Li, TH Li, YX Song, JX Sun, XW Chen… - Current …, 2022 - mdpi.com
The purpose of this meta-analysis was to evaluate the efficacy and safety of celecoxib, a
selective cyclooxygenase-2 (COX-2) inhibitor, in addition to standard anticancer therapy …

Soybean (Glycine max) INFOGEST Colonic Digests Attenuated Inflammatory Responses Based on Protein Profiles of Different Varieties

J Kusumah, ED Castañeda-Reyes, NA Bringe… - International journal of …, 2023 - mdpi.com
Soybean compounds have been established to modulate inflammation, but less is known
about how whole soybean compositions work together after digestion. The objective was to …

Recent advance of small-molecule drugs for clinical treatment of multiple myeloma

JH Zhao, QL Xu, S Ma, CY Li, HC Zhang… - European Journal of …, 2023 - Elsevier
Multiple myeloma (MM) is a hematologic neoplasm of plasma cells that is currently deemed
incurable. Despite the introduction of novel immunomodulators and proteasome inhibitors …

Effect of Lactobacillus fermentum ZS40 on the NF-κB signaling pathway in an azomethane-dextran sulfate sodium-induced colon cancer mouse model

J Liu, S Wang, R Yi, X Long, X Zhao - Frontiers in Microbiology, 2022 - frontiersin.org
The occurrence of intestinal diseases such as colon cancer is closely related to the intestinal
flora. Lactobacillus fermentum is a gut probiotic that plays an important role in chronic …