The emerging role of miRNAs in Merkel cell carcinoma pathogenesis: Signaling pathway crosstalk

NI Rizk, HM Midan, GK Helal, AI Abulsoud… - … -Research and Practice, 2023 - Elsevier
Merkel cell carcinoma (MCC) is an uncommon invasive form of skin cancer that typically
manifests as a nodule on the face, head, or neck that is flesh-colored or bluish-red in …

The potential role of miRNAs in the pathogenesis of salivary gland cancer–A Focus on signaling pathways interplay

AI Abulsoud, SS Elshaer, AA El-Husseiny… - … -Research and Practice, 2023 - Elsevier
Salivary gland cancer (SGC) is immensely heterogeneous, both in terms of its physical
manifestation and its aggressiveness. Developing a novel diagnostic and prognostic …

The potential role of miRNAs in the pathogenesis of adrenocortical carcinoma-A focus on signaling pathways interplay

HM Midan, GK Helal, AI Abulsoud, SS Elshaer… - … -Research and Practice, 2023 - Elsevier
Adrenocortical carcinoma (ACC) is a highly malignant infrequent tumor with a dismal
prognosis. microRNAs (miRNAs, miRs) are crucial in post-transcriptional gene expression …

[HTML][HTML] Telomerase RNA component lncRNA as potential diagnostic biomarker promotes CRC cellular migration and apoptosis evasion via modulation of β-catenin …

M Bakr, MA Abd-Elmawla, H Elimam, HG El-Din… - Non-coding RNA …, 2023 - Elsevier
Aim Long non-coding RNA (LncRNA) telomerase RNA component (TERC) has telomerase-
dependent and independent activity in numerous cancer types. The present study purposes …

The multiple roles of interferon regulatory factor family in health and disease

L Wang, Y Zhu, N Zhang, Y Xian, Y Tang, J Ye… - … and Targeted Therapy, 2024 - nature.com
Abstract Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly
influence the immune system, impacting both physiological and pathological processes …

Natural products and long noncoding RNA signatures in gallbladder cancer: a review focuses on pathogenesis, diagnosis, and drug resistance

H Elimam, NAA Alhamshry, A Hatawsh, N Elfar… - Naunyn-Schmiedeberg's …, 2024 - Springer
Gallbladder cancer (GBC) is an aggressive and lethal malignancy with a poor prognosis.
Long noncoding RNAs (lncRNAs) and natural products have emerged as key orchestrators …

Deciphering signaling pathway interplay via miRNAs in malignant pleural mesothelioma

A Salman, SSA Mageed, D Fathi, MA Elrebehy… - … -Research and Practice, 2023 - Elsevier
Malignant pleural mesothelioma (MPM) is a highly invasive form of lung cancer that
adversely affects the pleural and other linings of the lungs. MPM is a very aggressive tumor …

Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Parkinson's disease

OA Mohammed, MS Elballal, AA El-Husseiny… - … -Research and Practice, 2024 - Elsevier
Parkinson's disease (PD) is a debilitating neurological disorder characterized by the
impairment of the motor system, resulting in symptoms such as resting tremor, cogwheel …

Modulating miR-146a expression by hydrogen sulfide ameliorates motor dysfunction and axonal demyelination in cuprizone-induced multiple sclerosis

HR Ghaiad, MA Abd-Elmawla, ES Gad… - ACS Chemical …, 2023 - ACS Publications
Multiple sclerosis (MS) is a progressive neuro-inflammatory and neuro-autoimmune
disease. Although hydrogen sulfide has recently shown potential therapeutic impacts in …

Brain alarm by self-extracellular nucleic acids: From neuroinflammation to neurodegeneration

R Kunze, S Fischer, HH Marti, KT Preissner - Journal of Biomedical …, 2023 - Springer
Neurological disorders such as stroke, multiple sclerosis, as well as the neurodegenerative
diseases Parkinson's or Alzheimer's disease are accompanied or even powered by danger …