Role of Neuropilin-2-mediated signaling axis in cancer progression and therapy resistance
Neuropilins (NRPs) are transmembrane proteins involved in vascular and nervous system
development by regulating angiogenesis and axon guidance cues. Several published …
development by regulating angiogenesis and axon guidance cues. Several published …
Pharmacological modulation of ion channels for the treatment of cystic fibrosis
MC Pinto, IAL Silva, MF Figueira… - Journal of …, 2021 - Taylor & Francis
Cystic fibrosis (CF) is a life-shortening monogenic disease caused by mutations in the gene
encoding the CF transmembrane conductance regulator (CFTR) protein, an anion channel …
encoding the CF transmembrane conductance regulator (CFTR) protein, an anion channel …
CFTR interactome mapping using the mammalian membrane two‐hybrid high‐throughput screening system
SH Lim, J Snider, L Birimberg‐Schwartz… - Molecular systems …, 2022 - embopress.org
Abstract Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride and
bicarbonate channel in secretory epithelia with a critical role in maintaining fluid …
bicarbonate channel in secretory epithelia with a critical role in maintaining fluid …
Pathogenic relationships in cystic fibrosis and renal diseases: CFTR, SLC26A9 and anoctamins
K Kunzelmann, J Ousingsawat, A Kraus… - International journal of …, 2023 - mdpi.com
The Cl−-transporting proteins CFTR, SLC26A9, and anoctamin (ANO1; ANO6) appear to
have more in common than initially suspected, as they all participate in the pathogenic …
have more in common than initially suspected, as they all participate in the pathogenic …
Niclosamide, but not ivermectin, inhibits anoctamin 1 and 6 and attenuates inflammation of the respiratory tract
J Ousingsawat, R Centeio, R Schreiber… - … -European Journal of …, 2024 - Springer
Inflammatory airway diseases like cystic fibrosis, asthma and COVID-19 are characterized
by high levels of pulmonary cytokines. Two well-established antiparasitic drugs, niclosamide …
by high levels of pulmonary cytokines. Two well-established antiparasitic drugs, niclosamide …
The chloride anion as a signalling effector
ÁG Valdivieso, TA Santa‐Coloma - Biological Reviews, 2019 - Wiley Online Library
The specific role of the chloride anion (Cl−) as a signalling effector or second messenger
has been increasingly recognized in recent years. It could represent a key factor in the …
has been increasingly recognized in recent years. It could represent a key factor in the …
[HTML][HTML] VSI: The Anoctamins: Structure and Function:“Intracellular” anoctamins
K Kunzelmann, J Ousingsawat, R Schreiber - Cell Calcium, 2024 - Elsevier
Plasma membrane localized anoctamin 1, 2 and 6 (TMEM16A, B, F) have been examined in
great detail with respect to structure and function, but much less is known about the other …
great detail with respect to structure and function, but much less is known about the other …
ER–plasma membrane contact sites deliver ER lipids and proteins for rapid cell surface expansion
As a consequence of hypoosmotic shock, yeast cells swell rapidly and increase the surface
area by∼ 20% in 20 s. Approximately, 35% of this surface increase is mediated by the ER …
area by∼ 20% in 20 s. Approximately, 35% of this surface increase is mediated by the ER …
TMEM16A chloride channel does not drive mucus production
FB Simões, MC Quaresma, LA Clarke… - Life science …, 2019 - life-science-alliance.org
Airway mucus obstruction is the main cause of morbidity in cystic fibrosis, a disease caused
by mutations in the CFTR Cl− channel. Activation of non-CFTR Cl− channels such as …
by mutations in the CFTR Cl− channel. Activation of non-CFTR Cl− channels such as …
Development of novel therapeutics for all individuals with CF (the future goes on)
MD Amaral, PT Harrison - Journal of Cystic Fibrosis, 2023 - Elsevier
Despite the major advances and successes in finding and establishing new treatments that
tackle the basic defect in Cystic Fibrosis (CF), there is still an unmet need to bring these …
tackle the basic defect in Cystic Fibrosis (CF), there is still an unmet need to bring these …