Myelin is critical for healthy brain function. An accurate in vivo measure of myelin content
has important implications for understanding brain plasticity and neurodegenerative …

The image contrast in magnetic resonance imaging (MRI) is highly sensitive to several
mechanisms that are modulated by the properties of the tissue environment. The degree and …

Magnetization transfer contrast has yielded insight into brain tissue microstructure changes
across the lifespan and in a range of disorders. This progress has been aided by the …

MRI has become the most important paraclinical tool for diagnosing and monitoring patients
with multiple sclerosis (MS). However, conventional MRI sequences are largely nonspecific …

Diffusion MRI uses the random displacement of water molecules to sensitize the signal to
brain microstructure and to properties such as the density and shape of cells. Microstructure …

The cuprizone mouse model of demyelination was used to investigate the influence that
white matter changes have on different magnetic resonance imaging results. In vivo T2 …

Remyelination in the CNS is the natural process of damage repair in demyelinating
diseases such as multiple sclerosis (MS). However, remyelination becomes inadequate in …

Objective To determine the differences in motor pathways and selected non-motor pathways
of the basal ganglia in Parkinson's disease (PD) patients compared to healthy controls …

Huntington's disease is a genetic neurodegenerative disorder. White matter alterations have
recently been identified as a relevant pathophysiological feature of Huntington's disease, but …

Damage to myelin is a key feature of multiple sclerosis (MS) pathology. Magnetic resonance
imaging (MRI) has revolutionized our ability to detect and monitor MS pathology in vivo …