The impetus for developing methods for the construction of seven-membered rings derives
from the common occurrence of these frameworks in biologically active natural products. It is …

Reductive amination is an important tool for synthetic organic chemists in the construction of
carbon‐nitrogen bonds. This reaction, also termed reductive alkylation, involves …

A growing number of tetrahydropyran-containing biologically active substances are being
discovered from nature. Intramolecular oxa-conjugate cyclization (IOCC) is known as one of …

Intramolecular oxa-conjugate cyclization (IOCC) of α, β-unsaturated carbonyl compounds,
triggered by deprotonation with a base, represents a straightforward method for the …

The natural herbicide herboxidiene was constructed from two key fragments using a
modified Julia olefination based on the benzothiazolyl sulfone activator. Key steps in the …

The stereocontrolled formation of cis-2, 5-disubstituted tetrahydrofurans and cis-2, 6-
disubstituted tetrahydropyrans is achieved from enantiopure ketosulfinyl esters by reduction …

A convergent total synthesis of phorboxazole A (1a), from the C (3–19), C (20–27) and C (33–
46) fragments 5, 4 and 91, respectively, concentrating on stereocontrolled formation of the …

The phorboxazole natural products are among the most potent inhibitors of cancer cell
division, but they are essentially unavailable from natural sources at present. Laboratory …

We describe herein a concise synthesis of (+)‐neopeltolide, a marine macrolide natural
product that elicits a highly potent antiproliferative activity against several human cancer cell …

Synthetic Efforts toward the Macrolactone Core of Leucascandrolide A | The Journal of Organic
Chemistry ACS ACS Publications C&EN CAS Find my institution Log In The Journal of Organic …