Mental disorders represent common brain diseases characterized by substantial
impairments of social and cognitive functions. The neurobiological causes and mechanisms …

Anatomical, electrophysiological and behavioral studies in rodents have shown that the
thalamic midline nucleus reuniens (RE) is a crucial link in the communication between …

Frontotemporal dysconnectivity is a key pathology in schizophrenia. The specific nature of
this dysconnectivity is unknown, but animal models imply dysfunctional theta phase coupling …

We interrogated prefrontal circuit function in mice lacking Disrupted-in-schizophrenia-1
(Disc1-mutant mice), a risk factor for psychiatric disorders. Single-unit recordings in awake …

Memories are not formed in isolation. They are associated and organized into relational
knowledge structures that allow coherent thought. Failure to express such coherent thought …

Currently, the clinical diagnosis of schizophrenia relies solely on self-reporting and clinical
interview, and likely comprises heterogeneous biological subsets. Such subsets may be …

Schizophrenia is a chronic, debilitating disorder with diverse symptomatology, including
disorganized cognition and behavior. Despite considerable research effort, we have only a …

Elevated GSK-3 activity has been implicated in cognitive dysfunction associated with various
disorders including Alzheimer's disease, schizophrenia, type 2 diabetes, traumatic brain …

Deficits in social interaction or social cognition are key phenotypes in a variety of chronic
mental diseases, yet, their modeling and molecular dissection are only in their infancy. The …

Abstract Background Fragile X syndrome (FXS) is a common single gene cause of
intellectual disability and autism spectrum disorder. Cognitive inflexibility is one of the …