Molecular mechanisms of TDP-43 misfolding and pathology in amyotrophic lateral sclerosis
A Prasad, V Bharathi, V Sivalingam… - Frontiers in molecular …, 2019 - frontiersin.org
TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …
[HTML][HTML] The role of mitochondria in amyotrophic lateral sclerosis
Mitochondria are unique organelles that are essential for a variety of cellular processes
including energy metabolism, calcium homeostasis, lipid biosynthesis, and apoptosis …
including energy metabolism, calcium homeostasis, lipid biosynthesis, and apoptosis …
[HTML][HTML] Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …
neurodegenerative disorders that are thought to exist on a clinical and pathological …
A review of the molecular mechanisms of traumatic brain injury
AA Ladak, SA Enam, MT Ibrahim - World neurosurgery, 2019 - Elsevier
Traumatic brain injury (TBI) refers to any insult to the brain resulting in primary (direct) and
secondary (indirect) damage to the brain parenchyma. Secondary damage is often linked to …
secondary (indirect) damage to the brain parenchyma. Secondary damage is often linked to …
[HTML][HTML] TDP-43 proteinopathy and ALS: insights into disease mechanisms and therapeutic targets
Therapeutic options for patients with amyotrophic lateral sclerosis (ALS) are currently
limited. However, recent studies show that almost all cases of ALS, as well as tau-negative …
limited. However, recent studies show that almost all cases of ALS, as well as tau-negative …
Protein interaction networks in neurodegenerative diseases: From physiological function to aggregation
G Calabrese, C Molzahn, T Mayor - Journal of Biological Chemistry, 2022 - ASBMB
The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …
typically develop in older individuals, due to a combination of genetic and environmental …
Proteostasis failure in neurodegenerative diseases: focus on oxidative stress
A Höhn, A Tramutola, R Cascella - Oxidative medicine and …, 2020 - Wiley Online Library
Protein homeostasis or proteostasis is an essential balance of cellular protein levels
mediated through an extensive network of biochemical pathways that regulate different …
mediated through an extensive network of biochemical pathways that regulate different …
Aggregation of disordered proteins associated with neurodegeneration
Cellular deposition of protein aggregates, one of the hallmarks of neurodegeneration,
disrupts cellular functions and leads to neuronal death. Mutations, posttranslational …
disrupts cellular functions and leads to neuronal death. Mutations, posttranslational …
Pathomechanisms of TDP‐43 in neurodegeneration
Neurodegeneration, a term that refers to the progressive loss of structure and function of
neurons, is a feature of many neurodegenerative diseases such as amyotrophic lateral …
neurons, is a feature of many neurodegenerative diseases such as amyotrophic lateral …
Nilotinib effects in Parkinson's disease and dementia with Lewy bodies
Background: We evaluated the effects of low doses of the tyrosine kinase Abelson (Abl)
inhibitor Nilotinib, on safety and pharmacokinetics in Parkinson's disease dementia or …
inhibitor Nilotinib, on safety and pharmacokinetics in Parkinson's disease dementia or …