Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects
C Li, P Jiang, S Wei, X Xu, J Wang - Molecular cancer, 2020 - Springer
Regulatory T cells (Tregs) characterized by the expression of the master transcription factor
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …
Tissue regulatory T cells: regulatory chameleons
AR Muñoz-Rojas, D Mathis - Nature Reviews Immunology, 2021 - nature.com
Abstract The FOXP3+ CD4+ regulatory T (Treg) cells located in non-lymphoid tissues differ
in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have …
in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have …
Single-cell analyses of Crohn's disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions
Crohn's disease (CD) is a chronic transmural inflammation of intestinal segments caused by
dysregulated interaction between microbiome and gut immune system. Here, we profile, via …
dysregulated interaction between microbiome and gut immune system. Here, we profile, via …
Regulatory T cells in the face of the intestinal microbiota
Regulatory T cells (Treg cells) are key players in ensuring a peaceful coexistence with
microorganisms and food antigens at intestinal borders. Startling new information has …
microorganisms and food antigens at intestinal borders. Startling new information has …
A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model
A Kendirli, C de la Rosa, KF Lämmle, K Eglseer… - Nature …, 2023 - nature.com
Multiple sclerosis (MS) involves the infiltration of autoreactive T cells into the CNS, yet we
lack a comprehensive understanding of the signaling pathways that regulate this process …
lack a comprehensive understanding of the signaling pathways that regulate this process …
The role of transcription factors in shaping regulatory T cell identity
Forkhead box protein 3-expressing (FOXP3+) regulatory T cells (Treg cells) suppress
conventional T cells and are essential for immunological tolerance. FOXP3, the master …
conventional T cells and are essential for immunological tolerance. FOXP3, the master …
Human FOXP3 and tumour microenvironment
J Wang, R Gong, C Zhao, K Lei, X Sun, H Ren - Immunology, 2023 - Wiley Online Library
The tumour microenvironment (TME) is a complex system composed of cancer cells, stromal
cells and immune cells. Regulatory T cells (Tregs) in the TME impede immune surveillance …
cells and immune cells. Regulatory T cells (Tregs) in the TME impede immune surveillance …
Cognate microglia–T cell interactions shape the functional regulatory T cell pool in experimental autoimmune encephalomyelitis pathology
Z Haimon, GR Frumer, JS Kim, S Trzebanski… - Nature …, 2022 - nature.com
Microglia, the parenchymal brain macrophages of the central nervous system, have
emerged as critical players in brain development and homeostasis. The immune functions of …
emerged as critical players in brain development and homeostasis. The immune functions of …
TNF plays a crucial role in inflammation by signaling via T cell TNFR2
TNF, produced largely by T and innate immune cells, is potently proinflammatory, as are
cytokines such as IFN-γ and IL-17 produced by Th1 and Th17 cells, respectively. Here, we …
cytokines such as IFN-γ and IL-17 produced by Th1 and Th17 cells, respectively. Here, we …
CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells
T Ichikawa, K Hirahara, K Kokubo, M Kiuchi, A Aoki… - Nature …, 2019 - nature.com
Tissue-resident memory T cells (TRM cells) are crucial mediators of adaptive immunity in
nonlymphoid tissues. However, the functional heterogeneity and pathogenic roles of CD4+ …
nonlymphoid tissues. However, the functional heterogeneity and pathogenic roles of CD4+ …