Notch receptors and their cognate ligands transduce crucial signals between cells in various
tissues, and have been conserved across millions of years of evolution. Mutations in Notch …

The Notch signaling pathway has been demonstrated to play a critical role during
mammalian cardiac development based on recent findings from gene-targeted mice. In …

MicroRNAs (miRNAs) are genomically encoded small RNAs that hybridize with messenger
RNAs, resulting in degradation or translational inhibition of targeted transcripts. The …

Although hundreds of evolutionarily conserved microRNAs have been discovered, the
functions of most remain unknown. Here, we describe the embryonic spatiotemporal …

The Notch network regulates multiple cellular processes, including cell fate determination,
development, differentiation, proliferation, apoptosis, and regeneration. These processes …

Notch signaling is vital for proper cardiovascular development and function in both humans
and animal models. Indeed, mutations in either JAGGED or NOTCH cause congenital heart …

A variety of studies that are currently underway may validate the fruit fly as an in vivo model
for analyzing genes involved in cardiac function. Many mutations in conserved genetic …

The identification of the molecular mechanisms controlling cardiomyocyte proliferation
during the embryonic, fetal, and early neonatal life appears of paramount interest in regard …

Cardiac muscle creation during embryogenesis requires extracellular instructive signals that
are regulated precisely in time and space, intersecting with intracellular genetic programs …

The protein Numb does not live up to its name. This passive-sounding protein is anything
but spent. Originally identified as a cell-fate determinant in Drosophila development, Numb …