There are 2 populations of T lymphocytes, αβ T and γδ T cells, that can be distinguished by
the expression of either an αβ TCR or a γδ TCR, respectively. Pairing of the Ag binding …

The contributions of γδ T-cells to immunity to infection or tumors critically depend on their
activation and differentiation into effectors capable of secreting cytokines and killing infected …

The success of cancer immunotherapy depends on productive tumor cell recognition by
killer lymphocytes. γδ T cells are a population of innate-like lymphocytes endowed with …

On the path to successful immunotherapy of hematopoietic tumors, γδ T cells offer great
promise because of their human leukocyte antigen (HLA)–unrestricted targeting of a wide …

Abundant interferon-γ secretion, potent cytotoxicity, and major histocompatibility complex–
independent targeting of a large spectrum of tumors make γδ T cells attractive mediators of …

The pathogenesis of hepatosplenic T-cell lymphoma (HSTL), a rare entity mostly derived
from γδ T cells and usually with a fatal outcome, remains largely unknown. In this study …

The proliferation and interleukin-2 production of CD4+ CD25− αβ T cells were inhibited in a
cell-contact manner by Vδ2 γδ T cells. The transcription factor Helios was constitutively …

Abstract γδ T cells play key nonredundant roles in immunity to infections and tumors. Thus, it
is critical to understand the molecular mechanisms responsible for γδ T cell activation and …

Human Vγ9Vδ2 T cells, a major innate-like peripheral T cell subset, are thought to play in
vivo an important role in innate and adaptive immune responses to infection agents and …

Human Vγ9Vδ2 T cells are potent anti‐tumor lymphocytes that specifically respond to
pyrophosphate (phospho‐) antigens, which constitute the basis of current γδ T‐cell‐based …