With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Sphingolipids, including the two central bioactive lipids ceramide and sphingosine-1-
phosphate (S1P), have opposing roles in regulating cancer cell death and survival …

Lipid metabolism is regulated by multiple signaling pathways, and generates a variety of
bioactive lipid molecules. These bioactive lipid molecules known as signaling molecules …

Ceramides are involved in a variety of cellular processes and in disease. Their biological
functions are thought to depend on ceramides' unique biophysical properties, which …

Different studies corroborate a role for ceramide synthases and their downstream products,
ceramides, in modulation of apoptosis and autophagy in the context of cancer. These …

2014-11-12 Assigned to IMMATICS BIOTECHNOLOGIES GMBH reassignment IMMATICS
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

Sphingosine kinases (isoforms SK1 and SK2) catalyse the formation of a bioactive lipid,
sphingosine 1-phosphate (S1P). S1P is a well-established ligand of a family of five S1P …

Cisplatin and other platinum (II) analogs are widely used in clinical practice as anti-cancer
drugs for a wide range of tumors. The primary mechanism by which they exert their action is …

Signaling pathways regulated by mutant Fms-like tyrosine kinase 3 (FLT3)–internal tandem
duplication (ITD), which mediate resistance to acute myeloid leukemia (AML) cell death, are …

Alzheimer's disease (AD) is a chronic, progressive and irreversible neurodegenerative
disease with clinical characteristics of memory loss, dementia and cognitive impairment …