[HTML][HTML] Mechanotransduction in mammalian sensory hair cells
GA Caprara, AW Peng - Molecular and Cellular Neuroscience, 2022 - Elsevier
In the inner ear, the auditory and vestibular systems detect and translate sensory information
regarding sound and balance. The sensory cells that transform mechanical input into an …
regarding sound and balance. The sensory cells that transform mechanical input into an …
Structures of the TMC-1 complex illuminate mechanosensory transduction
The initial step in the sensory transduction pathway underpinning hearing and balance in
mammals involves the conversion of force into the gating of a mechanosensory transduction …
mammals involves the conversion of force into the gating of a mechanosensory transduction …
Beyond cell–cell adhesion: sensational cadherins for hearing and balance
A Jaiganesh, Y Narui… - Cold Spring …, 2018 - cshperspectives.cshlp.org
Cadherins form a large family of proteins often involved in calcium-dependent cellular
adhesion. Although classical members of the family can provide a physical bond between …
adhesion. Although classical members of the family can provide a physical bond between …
TMIE defines pore and gating properties of the mechanotransduction channel of mammalian cochlear hair cells
Summary TMC1 and TMC2 (TMC1/2) have been proposed to form the pore of the
mechanotransduction channel of cochlear hair cells. Here, we show that TMC1/2 cannot …
mechanotransduction channel of cochlear hair cells. Here, we show that TMC1/2 cannot …
The monoaminergic system is a bilaterian innovation
M Goulty, G Botton-Amiot, E Rosato… - Nature …, 2023 - nature.com
Monoamines like serotonin, dopamine, and adrenaline/noradrenaline (epinephrine/
norepinephrine) act as neuromodulators in the nervous system. They play a role in complex …
norepinephrine) act as neuromodulators in the nervous system. They play a role in complex …
Human TMC1 and TMC2 are mechanically gated ion channels
S Fu, X Pan, M Lu, J Dong, Z Yan - Neuron, 2024 - cell.com
Mammalian transmembrane channel-like proteins 1 and 2 (TMC1 and TMC2) have emerged
as very promising candidate mechanotransduction channels in hair cells. However …
as very promising candidate mechanotransduction channels in hair cells. However …
The tetraspan LHFPL5 is critical to establish maximal force sensitivity of the mechanotransduction channel of cochlear hair cells
The mechanoelectrical transduction (MET) channel of cochlear hair cells is gated by the tip
link, but the mechanisms that establish the exquisite force sensitivity of this MET channel are …
link, but the mechanisms that establish the exquisite force sensitivity of this MET channel are …
Subunits of the mechano-electrical transduction channel, Tmc1/2b, require Tmie to localize in zebrafish sensory hair cells
IV Pacentine, T Nicolson - PLoS genetics, 2019 - journals.plos.org
Mutations in transmembrane inner ear (TMIE) cause deafness in humans; previous studies
suggest involvement in the mechano-electrical transduction (MET) complex in sensory hair …
suggest involvement in the mechano-electrical transduction (MET) complex in sensory hair …
Function and dysfunction of TMC channels in inner ear hair cells
The TMC1 channel was identified as a protein essential for hearing in mouse and human,
and recognized as one of a family of eight such proteins in mammals. The TMC family is part …
and recognized as one of a family of eight such proteins in mammals. The TMC family is part …
Transmembrane channel-like (Tmc) subunits contribute to frequency sensitivity in the zebrafish utricle
P Sun, E Smith, T Nicolson - Journal of Neuroscience, 2024 - Soc Neuroscience
Information about dynamic head motion is conveyed by a central “striolar” zone of vestibular
hair cells and afferent neurons in the inner ear. How vestibular hair cells are tuned to …
hair cells and afferent neurons in the inner ear. How vestibular hair cells are tuned to …