Time-and space-resolved drug delivery is highly demanded for cancer treatment, which,
however, can barely be achieved with a traditional prodrug strategy. In recent years, the …

Bioorthogonal chemistry is a rapidly expanding field of research that involves the use of
small molecules that can react selectively with biomolecules in living cells and organisms …

Although the clearance of senescent cells has been proven to slow down the aging process
and promote anti‐cancer chemotherapy, the development of senolytics remains challenging …

Bioorthogonal decaging chemistry with both fast kinetics and high efficiency is highly
demanded for in vivo applications but remains very sporadic. Herein, we describe a new …

Antibody-drug conjugates (ADCs) are the most potent active tumor-targeting agents used
clinically. However, the preparation of ADCs with high drug-to-antibody ratios (DARs) …

The bioorthogonal tetrazine-triggered cleavage of trans-cyclooctene (TCO)-linked payloads
has strong potential for widespread use in drug delivery and in particular in click-cleavable …

Cancer is a major global health concern, and while chemotherapy remains a common
treatment, its non-specific toxicity and widespread distribution can cause systemic side …

Bioorthogonal reactions have revolutionized chemical biology by enabling selective
chemical transformations within living organisms and cells. This review comprehensively …

Bioorthogonal chemistry, recognized as a highly efficient tool in chemical biology, has
shown significant value in cancer treatment. The primary objective is to develop efficient …

Increasing the selectivity of chemotherapies by converting them into prodrugs that can be
activated at the tumour site decreases their side effects and allows discrimination between …