The neurotransmitters GABA and glycine mediate fast synaptic inhibition by activating ligand-
gated chloride channels—namely, type A GABA (GABAA) and glycine receptors. Both types …

Proper developmental, neural cell-type-specific, and activity-dependent regulation of
GABAergic transmission is essential for virtually all aspects of CNS function. The number of …

Repetitive transcranial magnetic stimulation (rTMS) is used as a therapeutic tool in
neurology and psychiatry. While repetitive magnetic stimulation (rMS) has been shown to …

In the nervous system, only one type of neuron–glial synapse is known to exist: that between
neurons and oligodendrocyte precursor cells (OPCs), yet their composition, assembly …

Gephyrin is a multifunctional protein responsible for molybdenum cofactor synthesis and the
clustering of glycine and GABA A receptors at inhibitory synapses. Based on the structure of …

Phase separation drives compartmentalization of intracellular contents into various
biomolecular condensates. Individual condensate components are thought to differentially …

Abstract Information processing in the brain depends on specialized organization of
neurotransmitter receptors and scaffolding proteins within the postsynaptic density …

Inhibitory synapses are also known as symmetric synapses due to their lack of prominent
postsynaptic densities (PSDs) under a conventional electron microscope (EM). Recent cryo …

TMEM16A/anoctamin-1 has been identified as a protein with the classic properties of a Ca
2+-activated chloride channel. Here, we used blue native polyacrylamide gel …

Scaffolding proteins underlying postsynaptic membrane specializations are important
structural and functional components of both excitatory and inhibitory synapses. At inhibitory …