Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN
QL Sievers, G Petzold, RD Bunker, A Renneville… - Science, 2018 - science.org
INTRODUCTION Thalidomide, lenalidomide, and pomalidomide are clinically approved
therapies for the treatment of multiple myeloma and other hematologic malignancies. These …
therapies for the treatment of multiple myeloma and other hematologic malignancies. These …
[HTML][HTML] OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis
Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most
members regulate cell-signaling cascades. Several OTU DUBs were reported to be ubiquitin …
members regulate cell-signaling cascades. Several OTU DUBs were reported to be ubiquitin …
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
The onset of inflammation is associated with reactive oxygen species and oxidative damage
to macromolecules like 7, 8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine …
to macromolecules like 7, 8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine …
[PDF][PDF] Crystallization screening: the influence of history on current practice
While crystallization historically predates crystallography, it is a critical step for the
crystallographic process. The rich history of crystallization and how that history influences …
crystallographic process. The rich history of crystallization and how that history influences …
CENP‐T provides a structural platform for outer kinetochore assembly
The kinetochore forms a dynamic interface with microtubules from the mitotic spindle during
mitosis. The Ndc80 complex acts as the key microtubule‐binding complex at kinetochores …
mitosis. The Ndc80 complex acts as the key microtubule‐binding complex at kinetochores …
AA16 Oxidoreductases Boost Cellulose-Active AA9 Lytic Polysaccharide Monooxygenases from Myceliophthora thermophila
Copper-dependent lytic polysaccharide monooxygenases (LPMOs) classified in Auxiliary
Activity (AA) families are considered indispensable as synergistic partners for cellulolytic …
Activity (AA) families are considered indispensable as synergistic partners for cellulolytic …
An enumerative algorithm for de novo design of proteins with diverse pocket structures
To create new enzymes and biosensors from scratch, precise control over the structure of
small-molecule binding sites is of paramount importance, but systematically designing …
small-molecule binding sites is of paramount importance, but systematically designing …
Microseed matrix screening for optimization in protein crystallization: what have we learned?
A D'Arcy, T Bergfors, SW Cowan-Jacob… - … Section F: Structural …, 2014 - journals.iucr.org
Protein crystals obtained in initial screens typically require optimization before they are of X-
ray diffraction quality. Seeding is one such optimization method. In classical seeding …
ray diffraction quality. Seeding is one such optimization method. In classical seeding …
[HTML][HTML] The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis
The HLA-DRB1 locus is strongly associated with rheumatoid arthritis (RA) susceptibility,
whereupon citrullinated self-peptides bind to HLA-DR molecules bearing the shared epitope …
whereupon citrullinated self-peptides bind to HLA-DR molecules bearing the shared epitope …
[HTML][HTML] Structural model of a CRISPR RNA-silencing complex reveals the RNA-target cleavage activity in Cmr4
The Cmr complex is an RNA-guided endonuclease that cleaves foreign RNA targets as part
of the CRISPR prokaryotic defense system. We investigated the molecular architecture of the …
of the CRISPR prokaryotic defense system. We investigated the molecular architecture of the …