The retina, an immune privileged tissue, has specialized immune defense mechanisms
against noxious insults that may exist in diseases such as age-related macular degeneration …

Neuroinflammation relying on the inflammatory responses of glial cells has emerged as an
impactful component of the multifactorial etiology of neurodegeneration in glaucoma. It has …

The role of microglia in degenerative and regenerative processes after damage of the
nervous system remains ambiguous, partially due to the paucity of appropriate investigative …

Dry eye disease (DED) is a multifactorial disease of the ocular surface, characterized by loss
of tear film homeostasis and ocular symptoms, in which neurosensory abnormalities have …

Glaucoma is a group of optic neuropathies characterized by the degeneration of retinal
ganglion cell axons and somas, ultimately preventing light signals in the retina from …

Using mice expressing green fluorescent protein (GFP) from a transgenic CD11c promoter
we found that a controlled optic nerve crush (ONC) injury attracted GFP hi retinal myeloid …

Ischemia-induced retinopathy is a hallmark finding of common visual disorders including
diabetic retinopathy (DR) and central retinal artery and vein occlusions. Treatments for …

Background Glaucoma is an optic neuropathy that is characterized by the loss of retinal
ganglion cells (RGCs) initiated by damage to axons in the optic nerve. The degeneration …

Purpose: We previously demonstrated that passive transfer of lymphocytes from
glaucomatous mice induces retinal ganglion cell (RGC) damage in recipient animals …

Neurodegeneration in glaucoma results in decline and loss of retinal ganglion cells (RGCs),
and is associated with activation of myeloid cells such as microglia and macrophages. The …