Studies of hemoglobin S haplotypes in African subpopulations have potential implications
for patient care and our understanding of genetic factors that have shaped the prevalence of …

Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

Introduction Evidence related to the national burden of Sickle Cell Disease (SCD) in Gulf
Cooperation Council (GCC) largely fragmented. Thus, the aim of this study is to systemically …

Introduction Stem cell therapy with bone marrow-derived mononuclear cells (BMMCs) is an
option for improving joint function in osteonecrosis of the femoral head (ONFH). Bone …

The chronic inflammatory state in sickle cell anemia (SCA) is associated with several factors
such as the following: endothelial damage; increased production of reactive oxygen species; …

The study estimated α-thalassemia (α-thal) prevalence and assessed its associations with
clinical and hematological features in a random sample of Brazilian children with sickle cell …

This chapter summarizes how a simple point mutation in the human genome has evolved to
become a global public health problem, as well as a remarkable example of evolutionary …

Sickle cell hemoglobin is the result of a mutation at the sixth amino acid position of the beta
(β) globin chain. The HBB* S gene is in linkage disequilibrium with five main haplotypes in …

In sickle cell anemia (SCA), beta S-globin haplotypes represent the ethnic group or
geographic region from which patients originated. The haplotypes include Senegal (SEN) …

Abstract Background/Aims: βS-Haplotype prevalence and its associations with clinical and
hematological characteristics were assessed in Brazilian children with sickle cell anemia or …