[HTML][HTML] Niche preclinical and clinical applications of photoacoustic imaging with endogenous contrast

S John, S Hester, M Basij, A Paul, M Xavierselvan… - Photoacoustics, 2023 - Elsevier
In the past decade, photoacoustic (PA) imaging has attracted a great deal of popularity as an
emergent diagnostic technology owing to its successful demonstration in both preclinical …

[HTML][HTML] The single-cell and spatial transcriptional landscape of human gastrulation and early brain development

B Zeng, Z Liu, Y Lu, S Zhong, S Qin, L Huang, Y Zeng… - Cell Stem Cell, 2023 - cell.com
The emergence of the three germ layers and the lineage-specific precursor cells
orchestrating organogenesis represent fundamental milestones during early embryonic …

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors

I Cebola, SA Rodríguez-Seguí, CHH Cho, J Bessa… - Nature cell …, 2015 - nature.com
The genomic regulatory programmes that underlie human organogenesis are poorly
understood. Pancreas development, in particular, has pivotal implications for pancreatic …

Measuring absolute RNA copy numbers at high temporal resolution reveals transcriptome kinetics in development

NDL Owens, IL Blitz, MA Lane, I Patrushev, JD Overton… - Cell reports, 2016 - cell.com
Transcript regulation is essential for cell function, and misregulation can lead to disease.
Despite technologies to survey the transcriptome, we lack a comprehensive understanding …

Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy

BR Burton, GJ Britton, H Fang, J Verhagen… - Nature …, 2014 - nature.com
Antigen-specific immunotherapy combats autoimmunity or allergy by reinstating
immunological tolerance to target antigens without compromising immune function …

[HTML][HTML] Next-generation sequencing and prenatal'omics: advanced diagnostics and new insights into human development

NL Vora, L Hui - Genetics in Medicine, 2018 - Elsevier
Prenatal genetics has evolved over the last decade to include application of new'omics
technologies to improve perinatal care. The clinical utility of these technologies when …

Auxin Response Factors promote organogenesis by chromatin-mediated repression of the pluripotency gene SHOOTMERISTEMLESS

Y Chung, Y Zhu, MF Wu, S Simonini, A Kuhn… - Nature …, 2019 - nature.com
Abstract Specification of new organs from transit amplifying cells is critical for higher
eukaryote development. In plants, a central stem cell pool maintained by the pluripotency …

Specific gene-regulation networks during the pre-implantation development of the pig embryo as revealed by deep sequencing

S Cao, J Han, J Wu, Q Li, S Liu, W Zhang, Y Pei… - BMC genomics, 2014 - Springer
Background Because few studies exist to describe the unique molecular network regulation
behind pig pre-implantation embryonic development (PED), genetic engineering in the pig …

The gene expression profiles in response to 102 traditional Chinese medicine (TCM) components: a general template for research on TCMs

C Lv, X Wu, X Wang, J Su, H Zeng, J Zhao, S Lin… - Scientific reports, 2017 - nature.com
Abstract Traditional Chinese medicines (TCMs) have important therapeutic value in long-
term clinical practice. However, because TCMs contain diverse ingredients and have …

Defining the nature of human pluripotent stem cell progeny

M Patterson, DN Chan, I Ha, D Case, Y Cui, BV Handel… - Cell research, 2012 - nature.com
While it is clear that human pluripotent stem cells (hPSCs) can differentiate to generate a
panoply of various cell types, it is unknown how closely in vitro development mirrors that …