Mast cells are crucial effector cells in allergic reactions, where IgE is the best known
mechanism to trigger their degranulation and release of a vast array of allergic mediators …

Brain “fog” is a constellation of symptoms that include reduced cognition, inability to
concentrate and multitask, as well as loss of short and long term memory. Brain “fog” …

This is the fourth iteration of this parameter entitled “The Diagnosis and Management of
Anaphylaxis.” The first anaphylaxis parameter was published in 1998 and the last in 2010 …

Introduction: An increasing number of patients present with multiple symptoms affecting
many organs including the brain due to multiple mediators released by mast cells. These …

Mast cells, like many other types of inflammatory cell, perform pleiotropic roles in
cardiometabolic diseases such as atherosclerosis, abdominal aortic aneurysms, obesity …

Mast cells are present in atherosclerotic lesions throughout their progression. The process of
atherogenesis itself is characterized by infiltration and retention of cholesterol-containing …

Stress is an important risk factor for modern chronic diseases, with distinct influences in
males and females. The sex specificity of the mammalian stress response contributes to the …

In patients with systemic mastocytosis (SM), several aspects of morbidity remain poorly
understood. We assessed the risk of solid cancers, cardiovascular disease, anaphylaxis …

Mast cells are potent actors involved in inflammatory reactions in various tissues, including
both in the intimal and the adventitial layers of atherosclerotic arteries. In the arterial intima …

Integrative genetic association methods have shown great promise in post-GWAS (genome-
wide association study) analyses, in which one of the most challenging tasks is identifying …