miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis

CE Condrat, DC Thompson, MG Barbu, OL Bugnar… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) represent a class of small, non-coding RNAs with the main roles of
regulating mRNA through its degradation and adjusting protein levels. In recent years …

Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers

R Hamam, D Hamam, KA Alsaleh, M Kassem… - Cell death & …, 2017 - nature.com
Effective management of breast cancer depends on early diagnosis and proper monitoring
of patients' response to therapy. However, these goals are difficult to achieve because of the …

Functions of lncRNA HOTAIR in lung cancer

G Loewen, J Jayawickramarajah, Y Zhuo… - Journal of hematology & …, 2014 - Springer
Long non-coding RNAs (lncRNAs) govern fundamental biochemical and cellular processes.
lncRNA HOX transcript antisense RNA (HOTAIR) represses gene expression through …

Metastatic breast cancer: the potential of miRNA for diagnosis and treatment monitoring

A McGuire, JAL Brown, MJ Kerin - Cancer and metastasis reviews, 2015 - Springer
Breast cancer affects approximately 12% women worldwide and results in 14% of all cancer-
related fatalities. Breast cancer is commonly categorized into one of four main subtypes …

Triple negative breast cancer: a review of present and future diagnostic modalities

SA Dass, KL Tan, R Selva Rajan, NF Mokhtar… - Medicina, 2021 - mdpi.com
Triple-negative breast cancer (TNBC) is an aggressive breast type of cancer with no
expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal …

Semi-supervised learning for potential human microRNA-disease associations inference

X Chen, GY Yan - Scientific reports, 2014 - nature.com
MicroRNAs play critical role in the development and progression of various diseases.
Predicting potential miRNA-disease associations from vast amount of biological data is an …

Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model

L Ma, F Reinhardt, E Pan, J Soutschek, B Bhat… - Nature …, 2010 - nature.com
MicroRNAs (miRNAs) are increasingly implicated in the regulation of metastasis. Despite
their potential as targets for anti-metastatic therapy, miRNAs have only been silenced in …

RWRMDA: predicting novel human microRNA–disease associations

X Chen, MX Liu, GY Yan - Molecular BioSystems, 2012 - pubs.rsc.org
Recently, more and more research has shown that microRNAs (miRNAs) play critical roles
in the development and progression of various diseases, but it is not easy to predict potential …

Tumour‐infiltrating T‐cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review

K Nosho, Y Baba, N Tanaka, K Shima… - The Journal of …, 2010 - Wiley Online Library
The abundance of tumour‐infiltrating T‐cells has been associated with microsatellite
instability (MSI) and a favourable prognosis in colorectal cancer. However, numerous …

Cellular disposal of miR23b by RAB27-dependent exosome release is linked to acquisition of metastatic properties

MS Ostenfeld, DK Jeppesen, JR Laurberg, AT Boysen… - Cancer research, 2014 - AACR
Exosomes are small secreted vesicles that can transfer their content to recipient cells. In
cancer, exosome secretion has been implicated in tumor growth and metastatic spread. In …