Female specific risk factors for the development of Alzheimer's disease neuropathology and cognitive impairment: Call for a precision medicine approach

C Udeh-Momoh, T Watermeyer - Ageing Research Reviews, 2021 - Elsevier
Alzheimer's disease (AD) includes a long asymptomatic stage, which precedes the formal
diagnosis of dementia. AD biomarker models provide a framework for precision medicine …

Latent profiles of modifiable dementia risk factors in later midlife: relationships with incident dementia, cognition, and neuroimaging outcomes

LY Xiong, M Wood Alexander, YY Wong, CY Wu… - Molecular …, 2024 - nature.com
Abstract In 2020, the Lancet Commission identified 12 modifiable factors that increase
population-level dementia risk. It is unclear if these risk factors co-occur among individuals …

[HTML][HTML] Females with type 2 diabetes are at higher risk for accelerated cognitive decline than males: CAROLINA-COGNITION study

C Verhagen, J Janssen, GJ Biessels… - Nutrition, Metabolism …, 2022 - Elsevier
Background and aim Cognitive dysfunction is increasingly recognized as an important
comorbidity of type 2 diabetes (T2D). We aimed to establish if the risk of accelerated …

Metabolic syndrome predictors of brain gray matter volume in an age-stratified community sample of 776 Mexican-American adults: Results from the genetics of brain …

E Kotkowski, LR Price, RA DeFronzo… - Frontiers in Aging …, 2022 - frontiersin.org
Introduction This project aimed to investigate the association between biometric components
of metabolic syndrome (MetS) with gray matter volume (GMV) obtained with magnetic …

Diastolic blood pressure variability in later life may be a key risk marker for cognitive decline

R Peters, Y Xu, R Eramudugolla, PS Sachdev… - …, 2022 - Am Heart Assoc
Background: There is an increasing awareness of the need to understand the interaction
between long-term blood pressure patterns and their impact on the brain and cognition …

Sex differences and modifiable dementia risk factors synergistically influence memory over the adult lifespan

AA LaPlume, L McKetton… - … & Disease Monitoring, 2022 - Wiley Online Library
Introduction More women than men develop Alzheimer's disease, yet women perform better
and show less decline on episodic memory measures, a contradiction that may be …

Differential associations of 6 adiposity indices with dementia in older adults: the MIND-China study

S Wang, Q Zhang, T Hou, Y Wang, X Han… - Journal of the American …, 2023 - Elsevier
Objectives The cross-sectional association between late-life obesity and dementia is often
explained by the obesity paradox. We assessed the potential differential associations of …

The relationship between diabetes and the dementia risk: a meta-analysis

F Cao, F Yang, J Li, W Guo, C Zhang, F Gao… - Diabetology & Metabolic …, 2024 - Springer
Background The link between diabetes and dementia risk is not well understood. This study
evaluates the factors linking diabetes to dementia onset, providing guidance for preventing …

PTP1B inhibitor claramine rescues diabetes-induced spatial learning and memory impairment in mice

M Wu, W Liao, R Zhang, Y Gao, T Chen, L Hua… - Molecular …, 2023 - Springer
Accumulating clinical and epidemiological studies indicate that learning and memory
impairment is more prevalent among people with diabetes mellitus (DM). PTP1B is a …

Relationships between body composition and cognitive impairment in hospitalised middle-aged type 2 diabetic patients

YS Li, YL Liu, JJ Wang, N Haghbin… - Diabetes, Metabolic …, 2023 - Taylor & Francis
Objective The aim of this study was to elucidate the relationship between specific body
composition and the risk of Cognitive Impairment (CI) in middle-aged Type 2 Diabetes …