The human genome contains over one million short tandem repeats. Expansion of a subset
of these repeat tracts underlies over fifty human disorders, including common genetic …

Short tandem repeat (STR) or microsatellite, expansions underlie more than 50 hereditary
neurological, neuromuscular and other diseases, including myotonic dystrophy types 1 …

Pancreatic ductal adenocarcinoma (PDA) is characterized by aggressive local invasion and
metastatic spread, leading to high lethality. Although driver gene mutations during PDA …

Over a third of the human genome is comprised of repetitive sequences, including more than
a million short tandem repeats (STRs). While studies of the pathologic consequences of …

PURPOSE OF REVIEW Myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2
(DM2) are genetic disorders affecting skeletal and smooth muscle, heart, brain, eyes, and …

Myotonic dystrophy (DM) is caused by expanded CTG/CCTG repeats, causing symptoms in
skeletal muscle, heart, and central nervous system (CNS). CNS issues are debilitating and …

Embryonic myogenesis is a temporally and spatially regulated process that generates
skeletal muscle of the trunk and limbs. During this process, mononucleated myoblasts …

The Rbfox family of splicing factors regulate alternative splicing during animal development
and in disease, impacting thousands of exons in the maturing brain, heart and muscle …

Abstract Myotonic dystrophy type 1 (DM1) is an RNA-dominant disease whose pathogenesis
stems from the functional loss of muscleblind-like RNA-binding proteins (RBPs), which …

The myotonic dystrophies are the commonest cause of adult-onset muscular dystrophy.
Phenotypes of DM1 and DM2 are similar, but there are some important differences …