Transcription–replication conflicts as a source of genome instability
Transcription and replication both require large macromolecular complexes to act on a DNA
template, yet these machineries cannot simultaneously act on the same DNA sequence …
template, yet these machineries cannot simultaneously act on the same DNA sequence …
Nuclear compartments: an incomplete primer to nuclear compartments, bodies, and genome organization relative to nuclear architecture
AS Belmont - Cold Spring Harbor perspectives in biology, 2022 - cshperspectives.cshlp.org
This work reviews nuclear compartments, defined broadly to include distinct nuclear
structures, bodies, and chromosome domains. It first summarizes original cytological …
structures, bodies, and chromosome domains. It first summarizes original cytological …
Real-time single-molecule imaging of transcriptional regulatory networks in living cells
Gene regulatory networks drive the specific transcriptional programmes responsible for the
diversification of cell types during the development of multicellular organisms. Although our …
diversification of cell types during the development of multicellular organisms. Although our …
Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS
In mammalian cell nuclei, the nuclear lamina (NL) underlies the nuclear envelope (NE) to
maintain nuclear structure. The nuclear lamins, the major structural components of the NL …
maintain nuclear structure. The nuclear lamins, the major structural components of the NL …
Live-cell imaging uncovers the relationship between histone acetylation, transcription initiation, and nucleosome mobility
Histone acetylation and RNA polymerase II phosphorylation are associated with
transcriptionally active chromatin, but their spatiotemporal relationship in live cells remains …
transcriptionally active chromatin, but their spatiotemporal relationship in live cells remains …
STREAMING-tag system reveals spatiotemporal relationships between transcriptional regulatory factors and transcriptional activity
Transcription is a dynamic process. To detect the dynamic relationship among protein
clusters of RNA polymerase II and coactivators, gene loci, and transcriptional activity, we …
clusters of RNA polymerase II and coactivators, gene loci, and transcriptional activity, we …
Imaging transcription elongation dynamics by new technologies unveils the organization of initiation and elongation in transcription factories
H Kimura, Y Sato - Current opinion in cell biology, 2022 - Elsevier
In mammalian cells, RNA polymerase II (RNAP2)-mediated transcription occurs in numerous
foci in the nucleus. Transcription foci detected by RNAP2 activity have often been called …
foci in the nucleus. Transcription foci detected by RNAP2 activity have often been called …
[HTML][HTML] Repetitive CREB-DNA interactions at gene loci predetermined by CBP induce activity-dependent gene expression in human cortical neurons
Y Atsumi, R Iwata, H Kimura, P Vanderhaeghen… - Cell Reports, 2024 - cell.com
Neuronal activity-dependent transcription plays a key role in plasticity and pathology in the
brain. An intriguing question is how neuronal activity controls gene expression via …
brain. An intriguing question is how neuronal activity controls gene expression via …
Transcriptional condensates and phase separation: condensing information across scales and mechanisms
Transcription is the fundamental process of gene expression, which in eukaryotes occurs
within the complex physicochemical environment of the nucleus. Decades of research have …
within the complex physicochemical environment of the nucleus. Decades of research have …
Chromatin expansion microscopy reveals nanoscale organization of transcription and chromatin
Nanoscale chromatin organization regulates gene expression. Although chromatin is
notably reprogrammed during zygotic genome activation (ZGA), the organization of …
notably reprogrammed during zygotic genome activation (ZGA), the organization of …