[HTML][HTML] Passive immunotherapy against SARS-CoV-2: from plasma-based therapy to single potent antibodies in the race to stay ahead of the variants

WR Strohl, Z Ku, Z An, SF Carroll, BA Keyt, LM Strohl - BioDrugs, 2022 - Springer
The COVID-19 pandemic is now approaching 2 years old, with more than 440 million people
infected and nearly six million dead worldwide, making it the most significant pandemic …

Outlook of therapeutic and diagnostic competency of nanobodies against SARS-CoV-2: A systematic review

H Aria, F Mahmoodi, HS Ghaheh, H Zare, M Heiat… - Analytical …, 2022 - Elsevier
Purpose The newly emerged coronavirus (SARS-CoV-2) continues to infect humans, and no
completely efficient treatment has yet been found. Antibody therapy is one way to control …

[HTML][HTML] Structural modeling of nanobodies: a benchmark of state-of-the-art artificial intelligence programs

MS Valdés-Tresanco, ME Valdés-Tresanco… - Molecules, 2023 - mdpi.com
The number of applications for nanobodies is steadily expanding, positioning these
molecules as fast-growing biologic products in the biotechnology market. Several of their …

[HTML][HTML] The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer

N Li, A Quan, D Li, J Pan, H Ren, G Hoeltzel… - Nature …, 2023 - nature.com
Heterogeneous antigen expression is a key barrier influencing the activity of chimeric
antigen receptor (CAR) T cells in solid tumors. Here, we develop CAR T cells targeting …

[HTML][HTML] Outsmarting Pathogens with Antibody Engineering

AN Qerqez, RP Silva, JA Maynard - Annual Review of Chemical …, 2023 - annualreviews.org
There is growing interest in identifying antibodies that protect against infectious diseases,
especially for high-risk individuals and pathogens for which no vaccine is yet available …

[HTML][HTML] Single-domain antibodies as therapeutics for respiratory RNA virus infections

K Huang, T Ying, Y Wu - Viruses, 2022 - mdpi.com
Over the years, infectious diseases with high morbidity and mortality disrupted human
healthcare systems and devastated economies globally. Respiratory viruses, especially …

Alpha to Omicron (Variants of Concern): Mutation Journey, Vaccines, and Therapy

M Hamad, DMH AlKhamach, LM Alsayadi… - Viral …, 2023 - liebertpub.com
Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) initially emerged in December 2019 and has subsequently expanded …

[HTML][HTML] Evolutionary progression of collective mutations in Omicron sub-lineages towards efficient RBD-hACE2: allosteric communications between and within viral …

V Barozi, AL Edkins, ÖT Bishop - Computational and Structural …, 2022 - Elsevier
The interaction between the Spike (S) protein of SARS-CoV-2 and the human angiotensin
converting enzyme 2 (hACE2) is essential for infection, and is a target for neutralizing …

[HTML][HTML] 噬菌体展示技术及其在抗病毒药物发现中的应用

许世琦, 贺子涵, 陶炳灼, 秦鑫 - 药学学报, 2022 - html.rhhz.net
新冠肺炎的大暴发再次引起了人们对于病毒感染性疾病的关注, 研发抗病毒药物对于已知的和
可能新出现的病毒都具有重要意义. 近年来, 多肽和蛋白质类药物正成为抗病毒药物研发领域的 …

[HTML][HTML] SARS-CoV-2 neutralizing camelid heavy-chain-only antibodies as powerful tools for diagnostic and therapeutic applications

A Schlör, S Hirschberg, GB Amor, TL Meister… - Frontiers in …, 2022 - frontiersin.org
Introduction The ongoing COVID-19 pandemic situation caused by SARS-CoV-2 and
variants of concern such as B. 1.617. 2 (Delta) and recently, B. 1.1. 529 (Omicron) is posing …