In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

The action potential of the squid giant axon is formed by just two voltage-dependent
conductances in the cell membrane, yet mammalian central neurons typically express more …

Abstract Analysis of the Kv3 subfamily of K+ channel subunits has lead to the discovery of a
new class of neuronal voltage-gated K+ channels characterized by positively shifted voltage …

In this review we take a physiological perspective on the role of voltage‐gated potassium
channels in an identified neuron in the auditory brainstem. The large number of KCN genes …

The intrinsic electrical characteristics of different types of neurons are shaped by the K+
channels they express. From among the more than 70 different K+ channel genes …

Fast, precise, and sustained synaptic transmission at high frequency is thought to be crucial
for the task of sound localization in the auditory brainstem. However, recordings from the …

Fast-spiking GABAergic interneurons of the neocortex and hippocampus fire high-frequency
trains of brief action potentials with little spike-frequency adaptation. How these striking …

Mutations in the potassium channel gene KCNQ4 underlie DFNA2, an autosomal dominant
form of progressive hearing loss in humans. In the mouse cochlea, the transcript has been …

In humans, the absence of Fragile X mental retardation protein (FMRP), an RNA-binding
protein, results in Fragile X syndrome, the most common inherited form of intellectual …

▪ Abstract Neurons in the cochlear ganglion and auditory brain stem nuclei preserve the
relative timing of action potentials passed through sequential synaptic levels. To accomplish …