DNA and RNA can adopt various secondary structures. Four-stranded G-quadruplex (G4)
structures form through self-recognition of guanines into stacked tetrads, and considerable …

Guanine-rich DNA sequences can fold into four-stranded, noncanonical secondary
structures called G-quadruplexes (G4s). G4s were initially considered a structural curiosity …

Background The binding of transcription factors (TF) to genomic targets is critical in the
regulation of gene expression. Short, double-stranded DNA sequence motifs are routinely …

G-quadruplexes are four-stranded DNA structures that are over-represented in gene
promoter regions and are viewed as emerging therapeutic targets in oncology, as …

Guanine-rich DNA sequences have the propensity to adopt four-stranded tetrahelical G-
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …

Myc (avian myelocytomatosis viral oncogene homolog) represents one of the most sought
after drug targets in cancer. Myc transcription factor is an essential regulator of cell growth …

Summary G-quadruplex (G4) is an important type of nucleic acid secondary structure. An
abundance of potential G4-forming sites have been shown to exist in genomes, leading to …

It is generally accepted that DNA predominantly exists in duplex form in cells. However,
under torsional stress imposed by active transcription, DNA can assume nonduplex …

A complete understanding of DNA double-helical structure discovered by James Watson
and Francis Crick in 1953, unveil the importance and significance of DNA. For the last seven …

G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures. Sequences with
the potential to form G4s are abundant in regulatory regions of the genome including …