Hemorrhagic blood failure: oxygen debt, coagulopathy, and endothelial damage

NJ White, KR Ward, S Pati, G Strandenes… - Journal of Trauma and …, 2017 - journals.lww.com
Trauma is responsible for 1 in 10 deaths worldwide and is the leading cause of death of
people less than 45 years old. 1 The two most common causes of death in trauma victims …

Cold-stored platelets: A product with function optimized for hemorrhage control

KM Reddoch-Cardenas, JA Bynum… - … and Apheresis Science, 2019 - Elsevier
Early administration of blood products following severe trauma is pivotal for establishing
hemostasis and achieving successful outcomes. Platelet transfusions, in particular, provide …

A pilot trial of platelets stored cold versus at room temperature for complex cardiothoracic surgery

G Strandenes, J Sivertsen, CK Bjerkvig… - …, 2020 - ingentaconnect.com
Background: This pilot trial focused on feasibility and safety to provide preliminary data to
evaluate the hemostatic potential of cold-stored platelets (2° to 6° C) compared with …

Effects of storage time prolongation on in vivo and in vitro characteristics of 4 C–stored platelets

M Stolla, SL Bailey, L Fang, L Fitzpatrick… - …, 2020 - Wiley Online Library
ABSTRACT BACKGROUND Cold (4° C)‐stored platelets are currently under investigation
for transfusion in bleeding patients. It is currently unknown how long cold‐stored platelets …

Quality assessment of established and emerging blood components for transfusion

JP Acker, DC Marks… - Journal of blood …, 2016 - Wiley Online Library
Blood is donated either as whole blood, with subsequent component processing, or through
the use of apheresis devices that extract one or more components and return the rest of the …

Optimizing whole blood storage: hemostatic function of 35‐day stored product in CPD, CP2D, and CPDA‐1 anticoagulants

MA Meledeo, GC Peltier, CS McIntosh, JA Bynum… - …, 2019 - Wiley Online Library
BACKGROUND Transitioning from whole blood (WB) to components developed from efforts
to maximize donor yield. Components are advantageous for specific derangements, but …

In vitro quality and platelet function of cold and delayed cold storage of apheresis platelet concentrates in platelet additive solution for 21 days

H Braathen, J Sivertsen, THF Lunde… - …, 2019 - Wiley Online Library
BACKGROUND Cold storage of platelets may extend shelf life compared to room
temperature storage. This study aimed to investigate in vitro platelet quality and function in …

Cold storage of platelets in platelet additive solution maintains mitochondrial integrity by limiting initiation of apoptosis‐mediated pathways

KM Reddoch‐Cardenas, GC Peltier, TC Chance… - …, 2021 - Wiley Online Library
Background Cold storage of platelets in plasma maintains hemostatic function and is an
attractive alternative to room temperature platelets (RTPs). We have recently shown that …

Physiology of cold-stored platelets

TM Getz - Transfusion and Apheresis Science, 2019 - Elsevier
Platelet transfusions are a life-saving medical intervention used for the treatment of
thrombocytopenia or hemorrhage. Extensive research has gone into trying to understand …

In Vitro Characterization and Metabolomic Analysis of Cold-Stored Platelets

HQW Zhao, K Serrano, D Stefanoni… - Journal of proteome …, 2021 - ACS Publications
Platelet concentrates are currently stored at room temperature (RP) under constant agitation
for up to 5–7 days depending on national regulations. However, platelet quality deteriorates …