S100A10 (p11) is an emerging player in the neurobiology of depression and antidepressant
actions. p11 was initially thought to be a modulator of serotonin receptor (5-HTR) trafficking …

Pharmacological and anatomical evidence suggests that abnormal glutamatergic
neurotransmission may be associated with the pathophysiology of depression. Compounds …

Ketamine produces rapid antidepressant effects at sub-anesthetic dosage through early and
sustained activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors …

Progressive dysfunction and loss of neurons ultimately culminates in the symptoms and
eventual fatality of prion disease, yet the pathways and mechanisms that lead to neuronal …

Background Major depressive disorder (MDD) is a heterogeneous and prevalent mental
disorder associated with increased morbidity, disability, and mortality. However, its …

Decreased hippocampal tropomyosin receptor kinase B (TrkB) level is implicated in the
pathophysiology of stress-induced mood disorder and cognitive decline. However, how TrkB …

Our understanding of the molecular pathology of posttraumatic stress disorder (PTSD) is
evolving due to advances in sequencing technologies. With the recent emergence of Oxford …

The delayed behavioral response to chronic antidepressants depends on dynamic changes
in the hippocampus. It was suggested that the antidepressant protein p11 and the chromatin …

Abstract Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs)
are key regulators during the process of synaptic plasticity in major depression disorder …

Abstract Neurensin-2 (Nrsn2) is a neuro-specific gene linked to neurodevelopmental
disorders and has recently been reported to function as a bidirectional emotional regulator …