Cytokines and chemokines involved in osteoarthritis pathogenesis

V Molnar, V Matišić, I Kodvanj, R Bjelica… - International journal of …, 2021 - mdpi.com
Osteoarthritis is a common cause of disability worldwide. Although commonly referred to as
a disease of the joint cartilage, osteoarthritis affects all joint tissues equally. The …

The role of inflammation in the pathogenesis of osteoarthritis

YY Chow, KY Chin - Mediators of inflammation, 2020 - Wiley Online Library
A joint is the point of connection between two bones in our body. Inflammation of the joint
leads to several diseases, including osteoarthritis, which is the concern of this review …

Pathological mechanisms and therapeutic outlooks for arthrofibrosis

KM Usher, S Zhu, G Mavropalias, JA Carrino, J Zhao… - Bone research, 2019 - nature.com
Arthrofibrosis is a fibrotic joint disorder that begins with an inflammatory reaction to insults
such as injury, surgery and infection. Excessive extracellular matrix and adhesions contract …

Adipose tissue is a critical regulator of osteoarthritis

KH Collins, KL Lenz, EN Pollitt… - Proceedings of the …, 2021 - National Acad Sciences
Osteoarthritis (OA), the leading cause of pain and disability worldwide, disproportionally
affects individuals with obesity. The mechanisms by which obesity leads to the onset and …

An evidence-based systematic review of human knee post-traumatic osteoarthritis (PTOA): timeline of clinical presentation and disease markers, comparison of knee …

CM Khella, R Asgarian, JM Horvath, B Rolauffs… - International Journal of …, 2021 - mdpi.com
Understanding the causality of the post-traumatic osteoarthritis (PTOA) disease process of
the knee joint is important for diagnosing early disease and developing new and effective …

[HTML][HTML] Osteoarthritis year in review: genetics, genomics, epigenetics

DA Young, MJ Barter, J Soul - Osteoarthritis and cartilage, 2022 - Elsevier
Objective In this review, we have highlighted the advances over the past year in genetics,
genomics and epigenetics in the field of osteoarthritis (OA). Methods A literature search of …

Interleukin-1-interleukin-17 signaling axis induces cartilage destruction and promotes experimental osteoarthritis

HS Na, JS Park, KH Cho, JY Kwon, JW Choi… - Frontiers in …, 2020 - frontiersin.org
Osteoarthritis (OA), which is the most common degenerative joint disorder, has been
considered a non-inflammatory disease with abnormal mechanics. Interleukin (IL)-17 is a …

[HTML][HTML] Osteoarthritis year in review 2018: biomarkers (biochemical markers)

FS Hosnijeh, SM Bierma-Zeinstra… - Osteoarthritis and …, 2019 - Elsevier
Objective The aim of this narrative review is to summarize important findings from
biochemical marker studies relevant to osteoarthritis (OA) in the context of new discoveries …

Interleukin-17A Causes Osteoarthritis-Like Transcriptional Changes in Human Osteoarthritis-Derived Chondrocytes and Synovial Fibroblasts In Vitro

JY Mimpen, MJ Baldwin, AP Cribbs, M Philpott… - Frontiers in …, 2021 - frontiersin.org
Increased interleukin (IL)-17A has been identified in joints affected by osteoarthritis (OA), but
it is unclear how IL-17A, and its family members IL-17AF and IL-17F, can contribute to …

The potential role of probiotics in the management of osteoarthritis pain: current status and future prospects

SO Rahman, F Bariguian, A Mobasheri - Current Rheumatology Reports, 2023 - Springer
Abstract Purpose of Review This narrative review article comprehensively explains the
pathophysiology of osteoarthritis (OA) pain perception, how the gut microbiota is correlated …