The regulation of antibody production is linked to the generation and maintenance of
plasmablasts and plasma cells from their B cell precursors. Plasmablasts are the rapidly …

Germinal centres (GCs) are involved in the selection of B cells secreting high-affinity
antibodies and are also the origin of most human B cell lymphomas. Recent progress has …

Diffuse large B cell lymphoma (DLBCL) is the most common B cell non-Hodgkin lymphoma
and remains incurable in around 40% of patients. Efforts to sequence the coding genome …

Effective and sustained inhibition of non-enzymatic oncogenic driver proteins is a major
pharmacological challenge. The clinical success of thalidomide analogues demonstrates …

Mutations in the gene encoding the KMT2D (or MLL2) methyltransferase are highly recurrent
and occur early during tumorigenesis in diffuse large B cell lymphoma (DLBCL) and …

Diffuse large B-cell lymphoma (DLBCL), the most frequent subtype of lymphoid malignancy,
remains a significant clinical challenge, as∼ 30% of patients are not cured. Over the past …

The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B cells and
targeted by somatic mutations in B cell lymphomas. Here, we find that EZH2 deletion or …

Diffuse large B cell lymphoma (DLBCL) is a highly heterogeneous lymphoid neoplasm with
variations in gene expression profiles and genetic alterations, which lead to substantial …

In many B-cell lymphomas, chromosomal translocations are biologic and diagnostic
hallmarks of disease. An intriguing subset is formed by the so-called double-hit (DH) …

Germinal centers (GCs) are sites of intense B cell proliferation and are central for T cell–
dependent antibody responses. However, the role of c-Myc, a key cell-cycle regulator, in this …