Natural killer (NK) cells are unique innate immune cells and manifest rapid and potent
cytotoxicity for cancer immunotherapy and pathogen removal without the requirement of …

Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and
rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic …

N6 methyladenosine (m6A) RNA methylation regulators play an important role in the
development of tumors. However, their function in esophageal cancer (EC) has not been …

The care of patients with oesophageal cancer or of individuals who have an elevated risk of
oesophageal cancer has changed dramatically. The epidemiology of squamous cell and …

Background The standard neoadjuvant treatments in patients with esophageal squamous
cell carcinoma (ESCC) still have either poor safety or efficacy. Better therapies are needed …

Background Immune checkpoint inhibitors combined with chemotherapy as a neoadjuvant
therapy have been applied to the treatment of esophageal squamous cell carcinoma …

Currently, the influence of the tumor microbiome on the effectiveness of immunotherapy
remains largely unknown. Intratumoural Fusobacterium nucleatum (Fn) functions as an …

The complexity and plasticity of the tumor microenvironment (TME) make it difficult to fully
understand the intratumoral regulation of different cell types and their activities …

Myeloid-derived suppressor cells (MDSCs) are a group of heterogeneous cells which are
abnormally accumulated during the differentiation of myeloid cells. Immunosuppression is …

Background Immune checkpoint (IC) blockades (ICBs) significantly improve patients' clinical
outcomes with solid tumors. Because the objective response rate of single-agent ICB is …