Environmental metabolomics: an emerging approach to study organism responses to environmental stressors

BP Lankadurai, EG Nagato… - Environmental …, 2013 - cdnsciencepub.com
Metabolomics is the analysis of endogenous and exogenous low molecular mass
metabolites within a cell, tissue, or biofluid of an organism in response to an external …

Metabolomics and diabetes: analytical and computational approaches

KM Sas, A Karnovsky, G Michailidis, S Pennathur - Diabetes, 2015 - Am Diabetes Assoc
Diabetes is characterized by altered metabolism of key molecules and regulatory pathways.
The phenotypic expression of diabetes and associated complications encompasses …

Metabolic signatures of youth exposure to mixtures of per-and polyfluoroalkyl substances: a multi-cohort study

JA Goodrich, DI Walker, J He, X Lin… - Environmental …, 2023 - ehp.niehs.nih.gov
Background: Exposure to per-and polyfluoroalkyl substances (PFAS) is ubiquitous and has
been associated with an increased risk of several cardiometabolic diseases. However, the …

[HTML][HTML] Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation

AR Johnson, Y Qin, AJ Cozzo, AJ Freemerman… - Molecular …, 2016 - Elsevier
Objective A novel approach to regulate obesity-associated adipose inflammation may be
through metabolic reprogramming of macrophages (MΦs). Broadly speaking, MΦs …

Advances in the molecular understanding of biological zinc transport

CA Blindauer - Chemical Communications, 2015 - pubs.rsc.org
Between 5 and 10% of all proteins of a given organism are estimated to require zinc for
function, and hence zinc is essential for almost any given metabolic process. It is therefore of …

Zinc homeostasis in Pseudomonas

V Ducret, D Gonzalez, K Perron - Biometals, 2023 - Springer
In the genus Pseudomonas, zinc homeostasis is mediated by a complete set of import and
export systems, whose expression is precisely controlled by three transcriptional regulators …

[HTML][HTML] Juggling cadmium detoxification and zinc homeostasis: a division of labour between the two C. elegans metallothioneins

YJ Essig, OI Leszczyszyn, N Almutairi… - Chemosphere, 2024 - Elsevier
The chemical properties of toxic cadmium and essential zinc are very similar, and organisms
require intricate mechanisms that drive selective handling of metals. Previously regarded as …

Impact of maternal BMI and gestational diabetes mellitus on maternal and cord blood metabolome: results from the PREOBE cohort study

E Shokry, L Marchioro, O Uhl, MG Bermúdez… - Acta …, 2019 - Springer
Aims Maternal obesity and gestational diabetes mellitus (GDM) were frequently reported to
be risk factors for obesity and diabetes in offspring. Our goal was to study the impact of …

Pharmacometabolomics reveals irinotecan mechanism of action in cancer patients

X Bao, J Wu, S Kim, P LoRusso… - The Journal of Clinical …, 2019 - Wiley Online Library
The purpose of this study was to identify early circulating metabolite changes implicated in
the mechanism of action of irinotecan, a DNA topoisomerase I inhibitor, in cancer patients. A …

[HTML][HTML] Kynurenine pathway dynamics in patients with schizophrenia spectrum disorders across the disease trajectory

C Kuuskmäe, MA Philips, K Kilk, L Haring, R Kangro… - Psychiatry …, 2023 - Elsevier
The aim of this study was to evaluate how schizophrenia spectrum disorders (SSD) and
applied long-term (5.1 years) antipsychotic (AP) treatment affect the serum levels of …